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Mdm2 promotes the rapid degradation of p53.
Haupt Y, Maya R, Kazaz A, Oren M. Haupt Y, et al. Nature. 1997 May 15;387(6630):296-9. doi: 10.1038/387296a0. Nature. 1997. PMID: 9153395
Regulation of p53: intricate loops and delicate balances.
Oren M, Damalas A, Gottlieb T, Michael D, Taplick J, Leal JF, Maya R, Moas M, Seger R, Taya Y, Ben-Ze'ev A. Oren M, et al. Biochem Pharmacol. 2002 Sep;64(5-6):865-71. doi: 10.1016/s0006-2952(02)01149-8. Biochem Pharmacol. 2002. PMID: 12213580 Retracted.
Regulation of p53: intricate loops and delicate balances.
Oren M, Damalas A, Gottlieb T, Michael D, Taplick J, Leal JF, Maya R, Moas M, Seger R, Taya Y, Ben-Ze'Ev A. Oren M, et al. Ann N Y Acad Sci. 2002 Nov;973:374-83. doi: 10.1111/j.1749-6632.2002.tb04669.x. Ann N Y Acad Sci. 2002. PMID: 12485897
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.
Khosravi R, Maya R, Gottlieb T, Oren M, Shiloh Y, Shkedy D. Khosravi R, et al. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14973-7. doi: 10.1073/pnas.96.26.14973. Proc Natl Acad Sci U S A. 1999. PMID: 10611322 Free PMC article.
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.
Maya R, Balass M, Kim ST, Shkedy D, Leal JF, Shifman O, Moas M, Buschmann T, Ronai Z, Shiloh Y, Kastan MB, Katzir E, Oren M. Maya R, et al. Genes Dev. 2001 May 1;15(9):1067-77. doi: 10.1101/gad.886901. Genes Dev. 2001. PMID: 11331603 Free PMC article.
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study.
Lev Bar-Or R, Maya R, Segel LA, Alon U, Levine AJ, Oren M. Lev Bar-Or R, et al. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11250-5. doi: 10.1073/pnas.210171597. Proc Natl Acad Sci U S A. 2000. PMID: 11016968 Free PMC article.
The loss of mdm2 induces p53-mediated apoptosis.
de Rozieres S, Maya R, Oren M, Lozano G. de Rozieres S, et al. Oncogene. 2000 Mar 23;19(13):1691-7. doi: 10.1038/sj.onc.1203468. Oncogene. 2000. PMID: 10763826
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