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More on 'the efficacy of antifolate antimalarial combinations in Africa'.
Watkins WM, Mberu EK, Winstanley PA, Plowe CV. Watkins WM, et al. Parasitol Today. 1999 Apr;15(4):131-2. doi: 10.1016/s0169-4758(99)01419-2. Parasitol Today. 1999. PMID: 10322331 No abstract available.
Plasmodium falciparum: in vitro activity of sulfadoxine and dapsone in field isolates from Kenya: point mutations in dihydropteroate synthase may not be the only determinants in sulfa resistance.
Mberu EK, Nzila AM, Nduati E, Ross A, Monks SM, Kokwaro GO, Watkins WM, Hopkins Sibley C. Mberu EK, et al. Exp Parasitol. 2002 Jun-Jul;101(2-3):90-6. doi: 10.1016/s0014-4894(02)00108-x. Exp Parasitol. 2002. PMID: 12427462
Japanese poor metabolizers of proguanil do not have an increased risk of malaria chemoprophylaxis breakthrough.
Mberu EK, Wansor T, Sato H, Nishikawa Y, Watkins WM. Mberu EK, et al. Trans R Soc Trop Med Hyg. 1995 Nov-Dec;89(6):658-9. doi: 10.1016/0035-9203(95)90434-4. Trans R Soc Trop Med Hyg. 1995. PMID: 8594689 No abstract available.
A single dose of intramuscular sulfadoxine-pyrimethamine as an adjunct to quinine in the treatment of severe malaria: pharmacokinetics and efficacy.
Newton CR, Winstanley PA, Watkins WM, Mwangi IN, Waruiru CM, Mberu EK, Warn PA, Nevill CG, Marsh K. Newton CR, et al. Trans R Soc Trop Med Hyg. 1993 Mar-Apr;87(2):207-10. doi: 10.1016/0035-9203(93)90495-c. Trans R Soc Trop Med Hyg. 1993. PMID: 8337731 Clinical Trial.
Genetic diversity of Plasmodium falciparum parasites from Kenya is not affected by antifolate drug selection.
Nzila AM, Mberu EK, Nduati E, Ross A, Watkins WM, Sibley CH. Nzila AM, et al. Among authors: mberu ek. Int J Parasitol. 2002 Nov;32(12):1469-76. doi: 10.1016/s0020-7519(02)00164-9. Int J Parasitol. 2002. PMID: 12392912 Clinical Trial.
The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya.
Mberu EK, Mosobo MK, Nzila AM, Kokwaro GO, Sibley CH, Watkins WM. Mberu EK, et al. Am J Trop Med Hyg. 2000 Mar;62(3):396-401. doi: 10.4269/ajtmh.2000.62.396. Am J Trop Med Hyg. 2000. PMID: 11037785 Clinical Trial.
Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum.
Nzila AM, Nduati E, Mberu EK, Hopkins Sibley C, Monks SA, Winstanley PA, Watkins WM. Nzila AM, et al. Among authors: mberu ek. J Infect Dis. 2000 Jun;181(6):2023-8. doi: 10.1086/315520. Epub 2000 Jun 5. J Infect Dis. 2000. PMID: 10837185
Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites.
Nzila AM, Mberu EK, Sulo J, Dayo H, Winstanley PA, Sibley CH, Watkins WM. Nzila AM, et al. Antimicrob Agents Chemother. 2000 Apr;44(4):991-6. doi: 10.1128/aac.44.4.991-996.2000. Antimicrob Agents Chemother. 2000. PMID: 10722502 Free PMC article.
Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain.
Nzila-Mounda A, Mberu EK, Sibley CH, Plowe CV, Winstanley PA, Watkins WM. Nzila-Mounda A, et al. Antimicrob Agents Chemother. 1998 Jan;42(1):164-9. doi: 10.1128/AAC.42.1.164. Antimicrob Agents Chemother. 1998. PMID: 9449279 Free PMC article.
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