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Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections.
Eapen MS, Lu W, Hackett TL, Singhera GK, Thompson IE, McAlinden KD, Hardikar A, Weber HC, Haug G, Wark PAB, Chia C, Sohal SS. Eapen MS, et al. Among authors: mcalinden kd. Am J Physiol Lung Cell Mol Physiol. 2021 Jan 1;320(1):L158-L163. doi: 10.1152/ajplung.00437.2020. Epub 2020 Nov 11. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 33174446 Free PMC article.
SARS-CoV-2 (COVID-19) Adhesion Site Protein Upregulation in Small Airways, Type 2 Pneumocytes, and Alveolar Macrophages of Smokers and COPD - Possible Implications for Interstitial Fibrosis.
Brake SJ, Eapen MS, McAlinden KD, Markos J, Haug G, Larby J, Chia C, Hardikar A, Singhera GK, Hackett TL, Lu W, Sohal SS. Brake SJ, et al. Among authors: mcalinden kd. Int J Chron Obstruct Pulmon Dis. 2022 Jan 11;17:101-115. doi: 10.2147/COPD.S329783. eCollection 2022. Int J Chron Obstruct Pulmon Dis. 2022. PMID: 35046647 Free PMC article.
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