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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.
Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NM, Jackson SP, Smith GC, Ashworth A. Farmer H, et al. Among authors: mccabe n. Nature. 2005 Apr 14;434(7035):917-21. doi: 10.1038/nature03445. Nature. 2005. PMID: 15829967
X-chromosome inactivation: X marks the spot for BRCA1.
Stone C, McCabe N, Ashworth A. Stone C, et al. Among authors: mccabe n. Curr Biol. 2003 Jan 21;13(2):R63-4. doi: 10.1016/s0960-9822(02)01430-6. Curr Biol. 2003. PMID: 12546807
DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1.
Martin SA, McCabe N, Mullarkey M, Cummins R, Burgess DJ, Nakabeppu Y, Oka S, Kay E, Lord CJ, Ashworth A. Martin SA, et al. Among authors: mccabe n. Cancer Cell. 2010 Mar 16;17(3):235-48. doi: 10.1016/j.ccr.2009.12.046. Cancer Cell. 2010. PMID: 20227038 Free PMC article.
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition.
McCabe N, Turner NC, Lord CJ, Kluzek K, Bialkowska A, Swift S, Giavara S, O'Connor MJ, Tutt AN, Zdzienicka MZ, Smith GC, Ashworth A. McCabe N, et al. Cancer Res. 2006 Aug 15;66(16):8109-15. doi: 10.1158/0008-5472.CAN-06-0140. Cancer Res. 2006. PMID: 16912188
BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency.
McCabe N, Lord CJ, Tutt AN, Martin NM, Smith GC, Ashworth A. McCabe N, et al. Cancer Biol Ther. 2005 Sep;4(9):934-6. doi: 10.4161/cbt.4.9.2141. Epub 2005 Sep 1. Cancer Biol Ther. 2005. PMID: 16251802
Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM.
McCabe N, Hanna C, Walker SM, Gonda D, Li J, Wikstrom K, Savage KI, Butterworth KT, Chen C, Harkin DP, Prise KM, Kennedy RD. McCabe N, et al. Cancer Res. 2015 Jun 1;75(11):2159-65. doi: 10.1158/0008-5472.CAN-14-3502. Epub 2015 Apr 13. Cancer Res. 2015. PMID: 25870146
Role played by BRCA1 in regulating the cellular response to stress.
Gilmore PM, Quinn JE, Mullan PB, Andrews HN, McCabe N, Carty M, Kennedy RD, Harkin DP. Gilmore PM, et al. Among authors: mccabe n. Biochem Soc Trans. 2003 Feb;31(Pt 1):257-62. Biochem Soc Trans. 2003. PMID: 12546697 Review.
We review the role played by BRCA1 in detecting and signalling the presence of DNA damage, particularly double-strand DNA breaks, and look at the evidence to support a role for BRCA1 in regulating stress response pathways such as the c-Jun N-terminal kinase/stress-activate …
We review the role played by BRCA1 in detecting and signalling the presence of DNA damage, particularly double-strand DNA breaks, and look a …
Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer.
Tutt AN, Lord CJ, McCabe N, Farmer H, Turner N, Martin NM, Jackson SP, Smith GC, Ashworth A. Tutt AN, et al. Among authors: mccabe n. Cold Spring Harb Symp Quant Biol. 2005;70:139-48. doi: 10.1101/sqb.2005.70.012. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869747
Targeting Tankyrase 1 as a therapeutic strategy for BRCA-associated cancer.
McCabe N, Cerone MA, Ohishi T, Seimiya H, Lord CJ, Ashworth A. McCabe N, et al. Oncogene. 2009 Mar 19;28(11):1465-70. doi: 10.1038/onc.2008.483. Epub 2009 Feb 2. Oncogene. 2009. PMID: 19182824
BRCA1 interacts with and is required for paclitaxel-induced activation of mitogen-activated protein kinase kinase kinase 3.
Gilmore PM, McCabe N, Quinn JE, Kennedy RD, Gorski JJ, Andrews HN, McWilliams S, Carty M, Mullan PB, Duprex WP, Liu ET, Johnston PG, Harkin DP. Gilmore PM, et al. Among authors: mccabe n. Cancer Res. 2004 Jun 15;64(12):4148-54. doi: 10.1158/0008-5472.CAN-03-4080. Cancer Res. 2004. PMID: 15205325
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