McCarthy JR - Search Results

1

Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists.

Guo Z, Tellew JE, Gross RS, Dyck B, Grey J, Haddach M, Kiankarimi M, Lanier M, Li BF, Luo Z, McCarthy JR, Moorjani M, Saunders J, Sullivan R, Zhang X, Zamani-Kord S, Grigoriadis DE, Crowe PD, Chen TK, Williams JP. Guo Z, et al. Among authors: mccarthy jr. J Med Chem. 2005 Aug 11;48(16):5104-7. doi: 10.1021/jm050384+. J Med Chem. 2005. PMID: 16078829

2

Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists.

Gross RS, Guo Z, Dyck B, Coon T, Huang CQ, Lowe RF, Marinkovic D, Moorjani M, Nelson J, Zamani-Kord S, Grigoriadis DE, Hoare SR, Crowe PD, Bu JH, Haddach M, McCarthy J, Saunders J, Sullivan R, Chen T, Williams JP. Gross RS, et al. J Med Chem. 2005 Sep 8;48(18):5780-93. doi: 10.1021/jm049085v. J Med Chem. 2005. PMID: 16134945

3

Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists.

Wilcoxen K, Huang CQ, McCarthy JR, Grigoriadis DE, Chen C. Wilcoxen K, et al. Among authors: mccarthy jr. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3367-70. doi: 10.1016/s0960-894x(03)00621-8. Bioorg Med Chem Lett. 2003. PMID: 12951127

4

Synthesis of 1-methyl-3-phenylpyrazolo[4,3-b]pyridines via a methylation of 4-phthalimino-3-phenylpyrazoles and optimization toward highly potent corticotropin-releasing factor type-1 antagonists.

Huang CQ, Wilcoxen K, McCarthy JR, Haddach M, Grigoriadis D, Chen C. Huang CQ, et al. Among authors: mccarthy jr. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3371-4. doi: 10.1016/s0960-894x(03)00622-x. Bioorg Med Chem Lett. 2003. PMID: 12951128

5

Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists.

Huang CQ, Wilcoxen K, McCarthy JR, Haddach M, Webb TR, Gu J, Xie YF, Grigoriadis DE, Chen C. Huang CQ, et al. Among authors: mccarthy jr. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3375-9. doi: 10.1016/s0960-894x(03)00684-x. Bioorg Med Chem Lett. 2003. PMID: 12951129

6

Design, synthesis, and SAR of 2-dialkylamino-4-arylpyrimidines as potent and selective corticotropin-releasing factor(1) (CRF(1)) receptor antagonists.

Huang CQ, Grigoriadis DE, Liu Z, McCarthy JR, Ramphal J, Webb T, Whitten JP, Xie MY, Chen C. Huang CQ, et al. Among authors: mccarthy jr. Bioorg Med Chem Lett. 2004 May 3;14(9):2083-6. doi: 10.1016/j.bmcl.2004.02.053. Bioorg Med Chem Lett. 2004. PMID: 15080983

7

Optimization of 3-phenylpyrazolo[1,5-a]pyrimidines as potent corticotropin-releasing factor-1 antagonists with adequate lipophilicity and water solubility.

Chen C, Wilcoxen KM, Huang CQ, McCarthy JR, Chen T, Grigoriadis DE. Chen C, et al. Among authors: mccarthy jr. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3669-73. doi: 10.1016/j.bmcl.2004.05.019. Bioorg Med Chem Lett. 2004. PMID: 15203140

8

Synthesis of benzoylpyrimidines as antagonists of the corticotropin-releasing factor-1 receptor.

Webb TR, Moran T, Huang CQ, McCarthy JR, Grigoriadis DE, Chen C. Webb TR, et al. Among authors: mccarthy jr. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3869-73. doi: 10.1016/j.bmcl.2004.05.072. Bioorg Med Chem Lett. 2004. PMID: 15225687

9

Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists.

Huang CQ, Wilcoxen KM, Grigoriadis DE, McCarthy JR, Chen C. Huang CQ, et al. Among authors: mccarthy jr. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3943-7. doi: 10.1016/j.bmcl.2004.05.056. Bioorg Med Chem Lett. 2004. PMID: 15225703

10

Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists.

Chen C, Wilcoxen KM, Huang CQ, Xie YF, McCarthy JR, Webb TR, Zhu YF, Saunders J, Liu XJ, Chen TK, Bozigian H, Grigoriadis DE. Chen C, et al. Among authors: mccarthy jr. J Med Chem. 2004 Sep 9;47(19):4787-98. doi: 10.1021/jm040058e. J Med Chem. 2004. PMID: 15341493

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