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What makes a good genetic association study?
Hattersley AT, McCarthy MI. Hattersley AT, et al. Among authors: mccarthy mi. Lancet. 2005 Oct 8;366(9493):1315-23. doi: 10.1016/S0140-6736(05)67531-9. Lancet. 2005. PMID: 16214603
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JR, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch AM, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin MR, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJ, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CN, Doney AS, Morris AD, Smith GD, Hattersley AT, McCarthy MI. Frayling TM, et al. Among authors: mccarthy mi. Science. 2007 May 11;316(5826):889-94. doi: 10.1126/science.1141634. Epub 2007 Apr 12. Science. 2007. PMID: 17434869 Free PMC article.
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS; Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT. Zeggini E, et al. Among authors: mccarthy mi. Science. 2007 Jun 1;316(5829):1336-41. doi: 10.1126/science.1142364. Epub 2007 Apr 26. Science. 2007. PMID: 17463249 Free PMC article.
Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
Freathy RM, Weedon MN, Bennett A, Hypponen E, Relton CL, Knight B, Shields B, Parnell KS, Groves CJ, Ring SM, Pembrey ME, Ben-Shlomo Y, Strachan DP, Power C, Jarvelin MR, McCarthy MI, Davey Smith G, Hattersley AT, Frayling TM. Freathy RM, et al. Among authors: mccarthy mi. Am J Hum Genet. 2007 Jun;80(6):1150-61. doi: 10.1086/518517. Epub 2007 Apr 23. Am J Hum Genet. 2007. PMID: 17503332 Free PMC article.
A common variant of HMGA2 is associated with adult and childhood height in the general population.
Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, Perry JR, Elliott KS, Hackett R, Guiducci C, Shields B, Zeggini E, Lango H, Lyssenko V, Timpson NJ, Burtt NP, Rayner NW, Saxena R, Ardlie K, Tobias JH, Ness AR, Ring SM, Palmer CN, Morris AD, Peltonen L, Salomaa V; Diabetes Genetics Initiative; Wellcome Trust Case Control Consortium, Davey Smith G, Groop LC, Hattersley AT, McCarthy MI, Hirschhorn JN, Frayling TM. Weedon MN, et al. Among authors: mccarthy mi. Nat Genet. 2007 Oct;39(10):1245-50. doi: 10.1038/ng2121. Epub 2007 Sep 2. Nat Genet. 2007. PMID: 17767157 Free PMC article.
723 results