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A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties.
Dooley K, McConnell RE, Xu K, Lewis ND, Haupt S, Youniss MR, Martin S, Sia CL, McCoy C, Moniz RJ, Burenkova O, Sanchez-Salazar J, Jang SC, Choi B, Harrison RA, Houde D, Burzyn D, Leng C, Kirwin K, Ross NL, Finn JD, Gaidukov L, Economides KD, Estes S, Thornton JE, Kulman JD, Sathyanarayanan S, Williams DE. Dooley K, et al. Among authors: mccoy c. Mol Ther. 2021 May 5;29(5):1729-1743. doi: 10.1016/j.ymthe.2021.01.020. Epub 2021 Jan 21. Mol Ther. 2021. PMID: 33484965 Free PMC article.
ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance.
Jang SC, Economides KD, Moniz RJ, Sia CL, Lewis N, McCoy C, Zi T, Zhang K, Harrison RA, Lim J, Dey J, Grenley M, Kirwin K, Ross NL, Bourdeau R, Villiger-Oberbek A, Estes S, Xu K, Sanchez-Salazar J, Dooley K, Dahlberg WK, Williams DE, Sathyanarayanan S. Jang SC, et al. Among authors: mccoy c. Commun Biol. 2021 Apr 22;4(1):497. doi: 10.1038/s42003-021-02004-5. Commun Biol. 2021. PMID: 33888863 Free PMC article.
Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12.
Lewis ND, Sia CL, Kirwin K, Haupt S, Mahimkar G, Zi T, Xu K, Dooley K, Jang SC, Choi B, Boutin A, Grube A, McCoy C, Sanchez-Salazar J, Doherty M, Gaidukov L, Estes S, Economides KD, Williams DE, Sathyanarayanan S. Lewis ND, et al. Among authors: mccoy c. Mol Cancer Ther. 2021 Mar;20(3):523-534. doi: 10.1158/1535-7163.MCT-20-0484. Epub 2020 Dec 21. Mol Cancer Ther. 2021. PMID: 33443094
Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity.
Kamerkar S, Leng C, Burenkova O, Jang SC, McCoy C, Zhang K, Dooley K, Kasera S, Zi T, Sisó S, Dahlberg W, Sia CL, Patel S, Schmidt K, Economides K, Soos T, Burzyn D, Sathyanarayanan S. Kamerkar S, et al. Among authors: mccoy c. Sci Adv. 2022 Feb 18;8(7):eabj7002. doi: 10.1126/sciadv.abj7002. Epub 2022 Feb 18. Sci Adv. 2022. PMID: 35179953 Free PMC article.
A Scanning Tunneling Microscopy Study of the Photoisomerization of Diazocine.
Dehiwala Liyanage C, Ortiz-Garcia JJ, Struckmeier A, McCoy CL, Kienzler MA, Quardokus RC. Dehiwala Liyanage C, et al. Among authors: mccoy cl. J Phys Chem Lett. 2024 Apr 8:4082-4087. doi: 10.1021/acs.jpclett.4c00096. Online ahead of print. J Phys Chem Lett. 2024. PMID: 38587451
Diffusion of excellence: evaluating a system to identify, replicate, and spread promising innovative practices across the Veterans health administration.
Jackson GL, Fix GM, White BS, Cutrona SL, Reardon CM, Damschroder LJ, Burns M, DeLaughter K, Opra Widerquist MA, Arasim M, Lindquist J, Gifford AL, King HA, Kaitz J, Jasuja GK, Hogan TP, Lopez JCF, Henderson B, Fitzgerald BA, Goetschius A, Hagan D, McCoy C, Seelig A, Nevedal A. Jackson GL, et al. Among authors: mccoy c. Front Health Serv. 2024 Feb 13;3:1223277. doi: 10.3389/frhs.2023.1223277. eCollection 2023. Front Health Serv. 2024. PMID: 38420338 Free PMC article.
632 results