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Preclinical studies in support of phase I/II clinical trials to treat GUCY2D-associated Leber congenital amaurosis.
Boye SL, O'Riordan C, Morris J, Lukason M, Compton D, Baek R, Elmore DM, Peterson JJ, Fajardo D, McCullough KT, Scaria A, McVie-Wylie A, Boye SE. Boye SL, et al. Among authors: mccullough kt. Mol Ther Methods Clin Dev. 2022 Dec 14;28:129-145. doi: 10.1016/j.omtm.2022.12.007. eCollection 2023 Mar 9. Mol Ther Methods Clin Dev. 2022. PMID: 36654798 Free PMC article.
Development of an AAV-CRISPR-Cas9-based treatment for dominant cone-rod dystrophy 6.
Mellen RW, Calabro KR, McCullough KT, Crosson SM, Cova A, Fajardo D, Xu E, Boye SL, Boye SE. Mellen RW, et al. Among authors: mccullough kt. Mol Ther Methods Clin Dev. 2023 Jun 1;30:48-64. doi: 10.1016/j.omtm.2023.05.020. eCollection 2023 Sep 14. Mol Ther Methods Clin Dev. 2023. PMID: 37361352 Free PMC article.
Intravitreal injection of a rationally designed AAV capsid library in non-human primate identifies variants with enhanced retinal transduction and neutralizing antibody evasion.
Kellish PC, Marsic D, Crosson SM, Choudhury S, Scalabrino ML, Strang CE, Hill J, McCullough KT, Peterson JJ, Fajardo D, Gupte S, Makal V, Kondratov O, Kondratova L, Iyer S, Witherspoon CD, Gamlin PD, Zolotukhin S, Boye SL, Boye SE. Kellish PC, et al. Among authors: mccullough kt. Mol Ther. 2023 Dec 6;31(12):3441-3456. doi: 10.1016/j.ymthe.2023.10.001. Epub 2023 Oct 9. Mol Ther. 2023. PMID: 37814449 Free article.
Postchallenge administration of brincidofovir protects healthy and immune-deficient mice reconstituted with limited numbers of T cells from lethal challenge with IHD-J-Luc vaccinia virus.
Zaitseva M, McCullough KT, Cruz S, Thomas A, Diaz CG, Keilholz L, Grossi IM, Trost LC, Golding H. Zaitseva M, et al. Among authors: mccullough kt. J Virol. 2015 Mar;89(6):3295-307. doi: 10.1128/JVI.03340-14. Epub 2015 Jan 14. J Virol. 2015. PMID: 25589648 Free PMC article.