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Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts.
Inai T, Mancuso M, Hashizume H, Baffert F, Haskell A, Baluk P, Hu-Lowe DD, Shalinsky DR, Thurston G, Yancopoulos GD, McDonald DM. Inai T, et al. Among authors: mcdonald dm. Am J Pathol. 2004 Jul;165(1):35-52. doi: 10.1016/S0002-9440(10)63273-7. Am J Pathol. 2004. PMID: 15215160 Free PMC article.
Rapid vascular regrowth in tumors after reversal of VEGF inhibition.
Mancuso MR, Davis R, Norberg SM, O'Brien S, Sennino B, Nakahara T, Yao VJ, Inai T, Brooks P, Freimark B, Shalinsky DR, Hu-Lowe DD, McDonald DM. Mancuso MR, et al. Among authors: mcdonald dm. J Clin Invest. 2006 Oct;116(10):2610-21. doi: 10.1172/JCI24612. J Clin Invest. 2006. PMID: 17016557 Free PMC article.
276 results