McDonald E - Search Results

1

Synthesis and SAR studies of potent HIV protease inhibitors containing novel dimethylphenoxyl acetates as P2 ligands.

Chen X, Kempf DJ, Li L, Sham HL, Vasavanonda S, Wideburg NE, Saldivar A, Marsh KC, McDonald E, Norbeck DW. Chen X, et al. Among authors: mcdonald e. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3657-60. doi: 10.1016/j.bmcl.2003.08.043. Bioorg Med Chem Lett. 2003. PMID: 14552751

2

Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.

Zhao C, Sham HL, Sun M, Stoll VS, Stewart KD, Lin S, Mo H, Vasavanonda S, Saldivar A, Park C, McDonald EJ, Marsh KC, Klein LL, Kempf DJ, Norbeck DW. Zhao C, et al. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5499-503. doi: 10.1016/j.bmcl.2005.08.093. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16203141

3

A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.

Sham HL, Zhao C, Stewart KD, Betebenner DA, Lin S, Park CH, Kong XP, Rosenbrook W Jr, Herrin T, Madigan D, Vasavanonda S, Lyons N, Molla A, Saldivar A, Marsh KC, McDonald E, Wideburg NE, Denissen JF, Robins T, Kempf DJ, Plattner JJ, Norbeck DW. Sham HL, et al. Among authors: mcdonald e. J Med Chem. 1996 Jan 19;39(2):392-7. doi: 10.1021/jm9507183. J Med Chem. 1996. PMID: 8558507

4

Novel azacyclic ureas that are potent inhibitors of HIV-1 protease.

Sham HL, Zhao C, Marsh KC, Betebenner DA, Lin S, Rosenbrook W Jr, Herrin T, Li L, Madigan D, Vasavanonda S, Molla A, Saldivar A, McDonald E, Wideburg NE, Kempf D, Norbeck DW, Plattner JJ. Sham HL, et al. Among authors: mcdonald e. Biochem Biophys Res Commun. 1996 Aug 14;225(2):436-40. doi: 10.1006/bbrc.1996.1191. Biochem Biophys Res Commun. 1996. PMID: 8753780

5

Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy.

Kempf DJ, Sham HL, Marsh KC, Flentge CA, Betebenner D, Green BE, McDonald E, Vasavanonda S, Saldivar A, Wideburg NE, Kati WM, Ruiz L, Zhao C, Fino L, Patterson J, Molla A, Plattner JJ, Norbeck DW. Kempf DJ, et al. Among authors: mcdonald e. J Med Chem. 1998 Feb 12;41(4):602-17. doi: 10.1021/jm970636+. J Med Chem. 1998. PMID: 9484509

6

ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease.

Sham HL, Kempf DJ, Molla A, Marsh KC, Kumar GN, Chen CM, Kati W, Stewart K, Lal R, Hsu A, Betebenner D, Korneyeva M, Vasavanonda S, McDonald E, Saldivar A, Wideburg N, Chen X, Niu P, Park C, Jayanti V, Grabowski B, Granneman GR, Sun E, Japour AJ, Leonard JM, Plattner JJ, Norbeck DW. Sham HL, et al. Among authors: mcdonald e. Antimicrob Agents Chemother. 1998 Dec;42(12):3218-24. doi: 10.1128/AAC.42.12.3218. Antimicrob Agents Chemother. 1998. PMID: 9835517 Free PMC article. Clinical Trial.

7

Potent piperazine hydroxyethylamine HIV protease inhibitors containing novel P3 ligands.

Chen X, Kempf DJ, Sham HL, Green BE, Molla A, Korneyeva M, Vasavanonda S, Wideburg NE, Saldivar A, Marsh KC, McDonald E, Norbeck DW. Chen X, et al. Among authors: mcdonald e. Bioorg Med Chem Lett. 1998 Dec 15;8(24):3531-6. doi: 10.1016/s0960-894x(98)00653-2. Bioorg Med Chem Lett. 1998. PMID: 9934466

8

ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

Kempf DJ, Marsh KC, Denissen JF, McDonald E, Vasavanonda S, Flentge CA, Green BE, Fino L, Park CH, Kong XP, et al. Kempf DJ, et al. Among authors: mcdonald e. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2484-8. doi: 10.1073/pnas.92.7.2484. Proc Natl Acad Sci U S A. 1995. PMID: 7708670 Free PMC article.

9

Potent inhibitors of the HIV-1 protease with good oral bioavailabilities.

Sham HL, Zhao C, Marsh KC, Betebenner DA, Lin S, McDonald E, Vasavanonda S, Wideburg N, Saldivar A, Robins T, et al. Sham HL, et al. Among authors: mcdonald e. Biochem Biophys Res Commun. 1995 Jun 6;211(1):159-65. doi: 10.1006/bbrc.1995.1791. Biochem Biophys Res Commun. 1995. PMID: 7779082

10

Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir.

Kempf DJ, Marsh KC, Kumar G, Rodrigues AD, Denissen JF, McDonald E, Kukulka MJ, Hsu A, Granneman GR, Baroldi PA, Sun E, Pizzuti D, Plattner JJ, Norbeck DW, Leonard JM. Kempf DJ, et al. Among authors: mcdonald e. Antimicrob Agents Chemother. 1997 Mar;41(3):654-60. doi: 10.1128/AAC.41.3.654. Antimicrob Agents Chemother. 1997. PMID: 9056009 Free PMC article.

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