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48 results
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Specific prediction of clinical QT prolongation by kinetic image cytometry in human stem cell derived cardiomyocytes.
Pfeiffer ER, Vega R, McDonough PM, Price JH, Whittaker R. Pfeiffer ER, et al. Among authors: mcdonough pm. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:263-73. doi: 10.1016/j.vascn.2016.04.007. Epub 2016 Apr 16. J Pharmacol Toxicol Methods. 2016. PMID: 27095424
High throughput measurement of Ca²⁺ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.
Cerignoli F, Charlot D, Whittaker R, Ingermanson R, Gehalot P, Savchenko A, Gallacher DJ, Towart R, Price JH, McDonough PM, Mercola M. Cerignoli F, et al. Among authors: mcdonough pm. J Pharmacol Toxicol Methods. 2012 Nov-Dec;66(3):246-56. doi: 10.1016/j.vascn.2012.08.167. Epub 2012 Aug 25. J Pharmacol Toxicol Methods. 2012. PMID: 22926323 Free PMC article.
Sorcin modulates mitochondrial Ca(2+) handling and reduces apoptosis in neonatal rat cardiac myocytes.
Suarez J, McDonough PM, Scott BT, Suarez-Ramirez A, Wang H, Fricovsky ES, Dillmann WH. Suarez J, et al. Among authors: mcdonough pm. Am J Physiol Cell Physiol. 2013 Feb 1;304(3):C248-56. doi: 10.1152/ajpcell.00039.2012. Epub 2012 Nov 14. Am J Physiol Cell Physiol. 2013. PMID: 23151801 Free PMC article.
Plasma membrane assays and three-compartment image cytometry for high content screening.
Prigozhina NL, Zhong L, Hunter EA, Mikić I, Callaway S, Roop DR, Mancini MA, Zacharias DA, Price JH, McDonough PM. Prigozhina NL, et al. Among authors: mcdonough pm. Assay Drug Dev Technol. 2007 Feb;5(1):29-48. doi: 10.1089/adt.2006.024. Assay Drug Dev Technol. 2007. PMID: 17355198
Assay of Calcium Transients and Synapses in Rat Hippocampal Neurons by Kinetic Image Cytometry and High-Content Analysis: An In Vitro Model System for Postchemotherapy Cognitive Impairment.
McDonough PM, Prigozhina NL, Basa RCB, Price JH. McDonough PM, et al. Assay Drug Dev Technol. 2017 Jul;15(5):220-236. doi: 10.1089/adt.2017.797. Assay Drug Dev Technol. 2017. PMID: 28723268 Free PMC article.
Quantification of lipid droplets and associated proteins in cellular models of obesity via high-content/high-throughput microscopy and automated image analysis.
McDonough PM, Agustin RM, Ingermanson RS, Loy PA, Buehrer BM, Nicoll JB, Prigozhina NL, Mikic I, Price JH. McDonough PM, et al. Assay Drug Dev Technol. 2009 Oct;7(5):440-60. doi: 10.1089/adt.2009.0196. Assay Drug Dev Technol. 2009. PMID: 19895345 Free PMC article.
Quantification of hormone sensitive lipase phosphorylation and colocalization with lipid droplets in murine 3T3L1 and human subcutaneous adipocytes via automated digital microscopy and high-content analysis.
McDonough PM, Ingermanson RS, Loy PA, Koon ED, Whittaker R, Laris CA, Hilton JM, Nicoll JB, Buehrer BM, Price JH. McDonough PM, et al. Assay Drug Dev Technol. 2011 Jun;9(3):262-80. doi: 10.1089/adt.2010.0302. Epub 2010 Dec 27. Assay Drug Dev Technol. 2011. PMID: 21186937 Free PMC article.
Differential phosphorylation of perilipin 1A at the initiation of lipolysis revealed by novel monoclonal antibodies and high content analysis.
McDonough PM, Maciejewski-Lenoir D, Hartig SM, Hanna RA, Whittaker R, Heisel A, Nicoll JB, Buehrer BM, Christensen K, Mancini MG, Mancini MA, Edwards DP, Price JH. McDonough PM, et al. PLoS One. 2013;8(2):e55511. doi: 10.1371/journal.pone.0055511. Epub 2013 Feb 6. PLoS One. 2013. PMID: 23405163 Free PMC article.
A live cell, image-based approach to understanding the enzymology and pharmacology of 2-bromopalmitate and palmitoylation.
Mikic I, Planey S, Zhang J, Ceballos C, Seron T, von Massenbach B, Watson R, Callaway S, McDonough PM, Price JH, Hunter E, Zacharias D. Mikic I, et al. Among authors: mcdonough pm. Methods Enzymol. 2006;414:150-87. doi: 10.1016/S0076-6879(06)14010-0. Methods Enzymol. 2006. PMID: 17110192
Identification of MicroRNAs that control lipid droplet formation and growth in hepatocytes via high-content screening.
Whittaker R, Loy PA, Sisman E, Suyama E, Aza-Blanc P, Ingermanson RS, Price JH, McDonough PM. Whittaker R, et al. Among authors: mcdonough pm. J Biomol Screen. 2010 Aug;15(7):798-805. doi: 10.1177/1087057110374991. Epub 2010 Jul 16. J Biomol Screen. 2010. PMID: 20639500
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