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The T4 glycoprotein is a cell-surface receptor for the AIDS virus.
McDougal JS, Maddon PJ, Dalgleish AG, Clapham PR, Littman DR, Godfrey M, Maddon DE, Chess L, Weiss RA, Axel R. McDougal JS, et al. Cold Spring Harb Symp Quant Biol. 1986;51 Pt 2:703-11. doi: 10.1101/sqb.1986.051.01.083. Cold Spring Harb Symp Quant Biol. 1986. PMID: 3495395
A soluble form of CD4 (T4) protein inhibits AIDS virus infection.
Deen KC, McDougal JS, Inacker R, Folena-Wasserman G, Arthos J, Rosenberg J, Maddon PJ, Axel R, Sweet RW. Deen KC, et al. Nature. 1988 Jan 7;331(6151):82-4. doi: 10.1038/331082a0. Nature. 1988. PMID: 3257544
HIV infection does not require endocytosis of its receptor, CD4.
Maddon PJ, McDougal JS, Clapham PR, Dalgleish AG, Jamal S, Weiss RA, Axel R. Maddon PJ, et al. Cell. 1988 Sep 9;54(6):865-74. doi: 10.1016/s0092-8674(88)91241-x. Cell. 1988. PMID: 3261635
Identification of the residues in human CD4 critical for the binding of HIV.
Arthos J, Deen KC, Chaikin MA, Fornwald JA, Sathe G, Sattentau QJ, Clapham PR, Weiss RA, McDougal JS, Pietropaolo C, et al. Arthos J, et al. Cell. 1989 May 5;57(3):469-81. doi: 10.1016/0092-8674(89)90922-7. Cell. 1989. PMID: 2541915
Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry.
McDougal JS, Nicholson JK, Cross GD, Cort SP, Kennedy MS, Mawle AC. McDougal JS, et al. J Immunol. 1986 Nov 1;137(9):2937-44. J Immunol. 1986. PMID: 2428879
Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds.
Rice WG, Schaeffer CA, Harten B, Villinger F, South TL, Summers MF, Henderson LE, Bess JW Jr, Arthur LO, McDougal JS, et al. Rice WG, et al. Nature. 1993 Feb 4;361(6411):473-5. doi: 10.1038/361473a0. Nature. 1993. PMID: 8429889
Structural features of CD4 required for binding to HIV.
Ibegbu CC, Kennedy MS, Maddon PJ, Deen KC, Hicks D, Sweet RW, McDougal JS. Ibegbu CC, et al. J Immunol. 1989 Apr 1;142(7):2250-6. J Immunol. 1989. PMID: 2538505
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