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Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae.
Begg SL, Eijkelkamp BA, Luo Z, Couñago RM, Morey JR, Maher MJ, Ong CL, McEwan AG, Kobe B, O'Mara ML, Paton JC, McDevitt CA. Begg SL, et al. Nat Commun. 2015 Mar 3;6:6418. doi: 10.1038/ncomms7418. Nat Commun. 2015. PMID: 25731976 Free PMC article.
An antioxidant role for catecholate siderophores in Salmonella.
Achard ME, Chen KW, Sweet MJ, Watts RE, Schroder K, Schembri MA, McEwan AG. Achard ME, et al. Biochem J. 2013 Sep 15;454(3):543-9. doi: 10.1042/BJ20121771. Biochem J. 2013. PMID: 23805839
Conjugative plasmid transfer and adhesion dynamics in an Escherichia coli biofilm.
Ong CL, Beatson SA, McEwan AG, Schembri MA. Ong CL, et al. Appl Environ Microbiol. 2009 Nov;75(21):6783-91. doi: 10.1128/AEM.00974-09. Epub 2009 Aug 28. Appl Environ Microbiol. 2009. PMID: 19717626 Free PMC article.
Copper(II)-bis(thiosemicarbazonato) complexes as anti-chlamydial agents.
Marsh JW, Djoko KY, McEwan AG, Huston WM. Marsh JW, et al. Pathog Dis. 2017 Sep 29;75(7). doi: 10.1093/femspd/ftx084. Pathog Dis. 2017. PMID: 28830076
The cytochrome bd-I respiratory oxidase augments survival of multidrug-resistant Escherichia coli during infection.
Shepherd M, Achard ME, Idris A, Totsika M, Phan MD, Peters KM, Sarkar S, Ribeiro CA, Holyoake LV, Ladakis D, Ulett GC, Sweet MJ, Poole RK, McEwan AG, Schembri MA. Shepherd M, et al. Sci Rep. 2016 Oct 21;6:35285. doi: 10.1038/srep35285. Sci Rep. 2016. PMID: 27767067 Free PMC article.
Copper(II)-Bis(Thiosemicarbazonato) Complexes as Antibacterial Agents: Insights into Their Mode of Action and Potential as Therapeutics.
Djoko KY, Goytia MM, Donnelly PS, Schembri MA, Shafer WM, McEwan AG. Djoko KY, et al. Antimicrob Agents Chemother. 2015 Oct;59(10):6444-53. doi: 10.1128/AAC.01289-15. Epub 2015 Aug 3. Antimicrob Agents Chemother. 2015. PMID: 26239980 Free PMC article.
Metal ions in macrophage antimicrobial pathways: emerging roles for zinc and copper.
Stafford SL, Bokil NJ, Achard ME, Kapetanovic R, Schembri MA, McEwan AG, Sweet MJ. Stafford SL, et al. Biosci Rep. 2013 Jul 16;33(4):e00049. doi: 10.1042/BSR20130014. Biosci Rep. 2013. PMID: 23738776 Free PMC article. Review.
Antimicrobial action of copper is amplified via inhibition of heme biosynthesis.
Djoko KY, McEwan AG. Djoko KY, et al. ACS Chem Biol. 2013 Oct 18;8(10):2217-23. doi: 10.1021/cb4002443. Epub 2013 Aug 22. ACS Chem Biol. 2013. PMID: 23895035
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