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The pivotal role of hepatocytes in drug discovery.
Soars MG, McGinnity DF, Grime K, Riley RJ. Soars MG, et al. Among authors: mcginnity df. Chem Biol Interact. 2007 May 20;168(1):2-15. doi: 10.1016/j.cbi.2006.11.002. Epub 2006 Nov 18. Chem Biol Interact. 2007. PMID: 17208208 Review.
Efficient assessment of the utility of immortalized Fa2N-4 cells for cytochrome P450 (CYP) induction studies using multiplex quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and substrate cassette methodologies.
Kenny JR, Chen L, McGinnity DF, Grime K, Shakesheff KM, Thomson B, Riley R. Kenny JR, et al. Among authors: mcginnity df. Xenobiotica. 2008 Dec;38(12):1500-17. doi: 10.1080/00498250802495846. Xenobiotica. 2008. PMID: 18989830
From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.
Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF, Ince F, Ingall AH, Kirk IP, Leeson PD, Leff P, Lewis RJ, Martin BP, McGinnity DF, Mortimore MP, Paine SW, Pairaudeau G, Patel A, Rigby AJ, Riley RJ, Teobald BJ, Tomlinson W, Webborn PJ, Willis PA. Springthorpe B, et al. Among authors: mcginnity df. Bioorg Med Chem Lett. 2007 Nov 1;17(21):6013-8. doi: 10.1016/j.bmcl.2007.07.057. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17827008
33 results