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The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors.
Liu SK, Fang N, Koretzky GA, McGlade CJ. Liu SK, et al. Among authors: mcglade cj. Curr Biol. 1999 Jan 28;9(2):67-75. doi: 10.1016/s0960-9822(99)80017-7. Curr Biol. 1999. PMID: 10021361
SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors.
McGlade CJ, Ellis C, Reedijk M, Anderson D, Mbamalu G, Reith AD, Panayotou G, End P, Bernstein A, Kazlauskas A, et al. McGlade CJ, et al. Mol Cell Biol. 1992 Mar;12(3):991-7. doi: 10.1128/mcb.12.3.991. Mol Cell Biol. 1992. PMID: 1372092 Free PMC article.
Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate.
Verdi JM, Schmandt R, Bashirullah A, Jacob S, Salvino R, Craig CG, Program AE, Lipshitz HD, McGlade CJ. Verdi JM, et al. Among authors: mcglade cj. Curr Biol. 1996 Sep 1;6(9):1134-45. doi: 10.1016/s0960-9822(02)70680-5. Curr Biol. 1996. PMID: 8805372
The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX.
Dho SE, Jacob S, Wolting CD, French MB, Rohrschneider LR, McGlade CJ. Dho SE, et al. Among authors: mcglade cj. J Biol Chem. 1998 Apr 10;273(15):9179-87. doi: 10.1074/jbc.273.15.9179. J Biol Chem. 1998. PMID: 9535908
Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.
Liu SK, McGlade CJ. Liu SK, et al. Among authors: mcglade cj. Oncogene. 1998 Dec 17;17(24):3073-82. doi: 10.1038/sj.onc.1202337. Oncogene. 1998. PMID: 9872323
Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells.
Schmandt R, Liu SK, McGlade CJ. Schmandt R, et al. Among authors: mcglade cj. Oncogene. 1999 Mar 11;18(10):1867-79. doi: 10.1038/sj.onc.1202507. Oncogene. 1999. PMID: 10086341
Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.
Dho SE, French MB, Woods SA, McGlade CJ. Dho SE, et al. Among authors: mcglade cj. J Biol Chem. 1999 Nov 12;274(46):33097-104. doi: 10.1074/jbc.274.46.33097. J Biol Chem. 1999. PMID: 10551880
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
Zhang W, Trible RP, Zhu M, Liu SK, McGlade CJ, Samelson LE. Zhang W, et al. Among authors: mcglade cj. J Biol Chem. 2000 Jul 28;275(30):23355-61. doi: 10.1074/jbc.M000404200. J Biol Chem. 2000. PMID: 10811803
The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR.
Liu SK, Smith CA, Arnold R, Kiefer F, McGlade CJ. Liu SK, et al. Among authors: mcglade cj. J Immunol. 2000 Aug 1;165(3):1417-26. doi: 10.4049/jimmunol.165.3.1417. J Immunol. 2000. PMID: 10903746
Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor.
Berry DM, Benn SJ, Cheng AM, McGlade CJ. Berry DM, et al. Among authors: mcglade cj. Oncogene. 2001 Mar 8;20(10):1203-11. doi: 10.1038/sj.onc.1204218. Oncogene. 2001. PMID: 11313864
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