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Modulation of RNA polymerase by (p)ppGpp reveals a RecG-dependent mechanism for replication fork progression.
McGlynn P, Lloyd RG. McGlynn P, et al. Cell. 2000 Mar 31;101(1):35-45. doi: 10.1016/S0092-8674(00)80621-2. Cell. 2000. PMID: 10778854
We have discovered a correlation between the ability of Escherichia coli cells to survive damage to DNA and their ability to modulate RNA polymerase via the stringent response regulators, (p)ppGpp. Elevation of (p)ppGpp, or certain mutations in the beta subunit of R …
We have discovered a correlation between the ability of Escherichia coli cells to survive damage to DNA and their ability to modulate RNA po …
The conserved C-terminus of the PcrA/UvrD helicase interacts directly with RNA polymerase.
Gwynn EJ, Smith AJ, Guy CP, Savery NJ, McGlynn P, Dillingham MS. Gwynn EJ, et al. Among authors: mcglynn p. PLoS One. 2013 Oct 16;8(10):e78141. doi: 10.1371/journal.pone.0078141. eCollection 2013. PLoS One. 2013. PMID: 24147116 Free PMC article.
Rep provides a second motor at the replisome to promote duplication of protein-bound DNA.
Guy CP, Atkinson J, Gupta MK, Mahdi AA, Gwynn EJ, Rudolph CJ, Moon PB, van Knippenberg IC, Cadman CJ, Dillingham MS, Lloyd RG, McGlynn P. Guy CP, et al. Among authors: mcglynn p. Mol Cell. 2009 Nov 25;36(4):654-66. doi: 10.1016/j.molcel.2009.11.009. Mol Cell. 2009. PMID: 19941825 Free PMC article.
Replication fork reversal and the maintenance of genome stability.
Atkinson J, McGlynn P. Atkinson J, et al. Among authors: mcglynn p. Nucleic Acids Res. 2009 Jun;37(11):3475-92. doi: 10.1093/nar/gkp244. Epub 2009 Apr 30. Nucleic Acids Res. 2009. PMID: 19406929 Free PMC article. Review.
Recombination and replication.
Syeda AH, Hawkins M, McGlynn P. Syeda AH, et al. Among authors: mcglynn p. Cold Spring Harb Perspect Biol. 2014 Oct 23;6(11):a016550. doi: 10.1101/cshperspect.a016550. Cold Spring Harb Perspect Biol. 2014. PMID: 25341919 Free PMC article. Review.
Helicases at the replication fork.
McGlynn P. McGlynn P. Adv Exp Med Biol. 2013;767:97-121. doi: 10.1007/978-1-4614-5037-5_5. Adv Exp Med Biol. 2013. PMID: 23161008
Holliday junction binding and resolution by the Rap structure-specific endonuclease of phage lambda.
Sharples GJ, Curtis FA, McGlynn P, Bolt EL. Sharples GJ, et al. Among authors: mcglynn p. J Mol Biol. 2004 Jul 16;340(4):739-51. doi: 10.1016/j.jmb.2004.05.030. J Mol Biol. 2004. PMID: 15223317
DNA replication roadblocks caused by Cascade interference complexes are alleviated by RecG DNA repair helicase.
Killelea T, Hawkins M, Howard JL, McGlynn P, Bolt EL. Killelea T, et al. Among authors: mcglynn p. RNA Biol. 2019 Apr;16(4):543-548. doi: 10.1080/15476286.2018.1496773. Epub 2018 Aug 10. RNA Biol. 2019. PMID: 30096986 Free PMC article.
Replication fork blockage by transcription factor-DNA complexes in Escherichia coli.
Payne BT, van Knippenberg IC, Bell H, Filipe SR, Sherratt DJ, McGlynn P. Payne BT, et al. Among authors: mcglynn p. Nucleic Acids Res. 2006;34(18):5194-202. doi: 10.1093/nar/gkl682. Epub 2006 Sep 25. Nucleic Acids Res. 2006. PMID: 17000639 Free PMC article.
The RdgC protein of Escherichia coli binds DNA and counters a toxic effect of RecFOR in strains lacking the replication restart protein PriA.
Moore T, McGlynn P, Ngo HP, Sharples GJ, Lloyd RG. Moore T, et al. Among authors: mcglynn p. EMBO J. 2003 Feb 3;22(3):735-45. doi: 10.1093/emboj/cdg048. EMBO J. 2003. PMID: 12554673 Free PMC article.
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