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Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.
Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Pérez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X. Davies KJ, et al. FASEB J. 2007 Oct;21(12):3023-8. doi: 10.1096/fj.06-7246com. Epub 2007 Jun 26. FASEB J. 2007. PMID: 17595344 No abstract available.
Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion.
Yamamoto Y, Wang X, Bertrand D, Kern F, Zhang T, Duleba M, Srivastava S, Khor CC, Hu Y, Wilson LH, Blaszyk H, Rolshud D, Teh M, Liu J, Howitt BE, Vincent M, Crum CP, Nagarajan N, Ho KY, McKeon F, Xian W. Yamamoto Y, et al. Nat Commun. 2016 Jan 19;7:10380. doi: 10.1038/ncomms10380. Nat Commun. 2016. PMID: 26783136 Free PMC article.
p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.
Zuo W, Zhang T, Wu DZ, Guan SP, Liew AA, Yamamoto Y, Wang X, Lim SJ, Vincent M, Lessard M, Crum CP, Xian W, McKeon F. Zuo W, et al. Nature. 2015 Jan 29;517(7536):616-20. doi: 10.1038/nature13903. Epub 2014 Nov 12. Nature. 2015. PMID: 25383540 Free PMC article.
Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome.
Dulloo I, Phang BH, Othman R, Tan SY, Vijayaraghavan A, Goh LK, Martin-Lopez M, Marques MM, Li CW, Wang de Y, Marín MC, Xian W, McKeon F, Sabapathy K. Dulloo I, et al. Nat Cell Biol. 2015 Apr;17(4):511-23. doi: 10.1038/ncb3130. Epub 2015 Mar 16. Nat Cell Biol. 2015. PMID: 25774835
Cloning and variation of ground state intestinal stem cells.
Wang X, Yamamoto Y, Wilson LH, Zhang T, Howitt BE, Farrow MA, Kern F, Ning G, Hong Y, Khor CC, Chevalier B, Bertrand D, Wu L, Nagarajan N, Sylvester FA, Hyams JS, Devers T, Bronson R, Lacy DB, Ho KY, Crum CP, McKeon F, Xian W. Wang X, et al. Nature. 2015 Jun 11;522(7555):173-8. doi: 10.1038/nature14484. Epub 2015 Jun 3. Nature. 2015. PMID: 26040716 Free PMC article.
Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo.
Chan B, Greenan G, McKeon F, Ellenberger T. Chan B, et al. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13075-80. doi: 10.1073/pnas.0503846102. Epub 2005 Aug 30. Proc Natl Acad Sci U S A. 2005. PMID: 16131541 Free PMC article.
Targeted deletion of the calcineurin inhibitor DSCR1 suppresses tumor growth.
Ryeom S, Baek KH, Rioth MJ, Lynch RC, Zaslavsky A, Birsner A, Yoon SS, McKeon F. Ryeom S, et al. Cancer Cell. 2008 May;13(5):420-31. doi: 10.1016/j.ccr.2008.02.018. Cancer Cell. 2008. PMID: 18455125
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species.
Ellisen LW, Ramsayer KD, Johannessen CM, Yang A, Beppu H, Minda K, Oliner JD, McKeon F, Haber DA. Ellisen LW, et al. Mol Cell. 2002 Nov;10(5):995-1005. doi: 10.1016/s1097-2765(02)00706-2. Mol Cell. 2002. PMID: 12453409
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