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327 results
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Detection of HIV-1 in Entamoeba histolytica without evidence of transmission to human cells.
Brown M, Reed S, Levy JA, Busch M, McKerrow JH. Brown M, et al. Among authors: mckerrow jh. AIDS. 1991 Jan;5(1):93-6. doi: 10.1097/00002030-199101000-00014. AIDS. 1991. PMID: 2059366
Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model.
Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL Jr, Reed SL. Meléndez-López SG, et al. Eukaryot Cell. 2007 Jul;6(7):1130-6. doi: 10.1128/EC.00094-07. Epub 2007 May 18. Eukaryot Cell. 2007. PMID: 17513563 Free PMC article.
A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target.
He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL. He C, et al. J Biol Chem. 2010 Jun 11;285(24):18516-27. doi: 10.1074/jbc.M109.086181. Epub 2010 Apr 8. J Biol Chem. 2010. PMID: 20378535 Free PMC article.
Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica.
Shahinas D, Debnath A, Benedict C, McKerrow JH, Pillai DR. Shahinas D, et al. Among authors: mckerrow jh. Front Microbiol. 2015 Apr 28;6:368. doi: 10.3389/fmicb.2015.00368. eCollection 2015. Front Microbiol. 2015. PMID: 26029171 Free PMC article.
X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.
Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. Parsonage D, et al. Among authors: mckerrow jh. J Struct Biol. 2016 May;194(2):180-90. doi: 10.1016/j.jsb.2016.02.015. Epub 2016 Feb 12. J Struct Biol. 2016. PMID: 26876147 Free PMC article.
Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.
Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. Debnath A, et al. Among authors: mckerrow jh. Antimicrob Agents Chemother. 2014 Jul;58(7):4138-44. doi: 10.1128/AAC.02576-14. Epub 2014 May 12. Antimicrob Agents Chemother. 2014. PMID: 24820073 Free PMC article.
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.
Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. Debnath A, et al. Among authors: mckerrow jh. Nat Med. 2012 Jun;18(6):956-60. doi: 10.1038/nm.2758. Nat Med. 2012. PMID: 22610278 Free PMC article.
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J, Fletterick RJ, Rosenthal PJ, Abrahamson M, Brinen LS, Rossi A, Sali A, McKerrow JH. Wang SX, et al. Among authors: mckerrow jh. Structure. 2007 May;15(5):535-43. doi: 10.1016/j.str.2007.03.012. Structure. 2007. PMID: 17502099
Transcriptional and secretory responses of Entamoeba histolytica to mucins, epithelial cells and bacteria.
Debnath A, Tashker JS, Sajid M, McKerrow JH. Debnath A, et al. Among authors: mckerrow jh. Int J Parasitol. 2007 Jul;37(8-9):897-906. doi: 10.1016/j.ijpara.2007.01.016. Epub 2007 Feb 12. Int J Parasitol. 2007. PMID: 17362964
A surface amebic cysteine proteinase inactivates interleukin-18.
Que X, Kim SH, Sajid M, Eckmann L, Dinarello CA, McKerrow JH, Reed SL. Que X, et al. Among authors: mckerrow jh. Infect Immun. 2003 Mar;71(3):1274-80. doi: 10.1128/iai.71.3.1274-1280.2003. Infect Immun. 2003. PMID: 12595442 Free PMC article.
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