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The major neutral proteinase of Entamoeba histolytica.
Keene WE, Petitt MG, Allen S, McKerrow JH. Keene WE, et al. Among authors: mckerrow jh. J Exp Med. 1986 Mar 1;163(3):536-49. doi: 10.1084/jem.163.3.536. J Exp Med. 1986. PMID: 2869098 Free PMC article.
Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model.
Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL Jr, Reed SL. Meléndez-López SG, et al. Eukaryot Cell. 2007 Jul;6(7):1130-6. doi: 10.1128/EC.00094-07. Epub 2007 May 18. Eukaryot Cell. 2007. PMID: 17513563 Free PMC article.
A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target.
He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, Houpt ER, Brinen LS, Craik CS, Roush WR, McKerrow J, Reed SL. He C, et al. J Biol Chem. 2010 Jun 11;285(24):18516-27. doi: 10.1074/jbc.M109.086181. Epub 2010 Apr 8. J Biol Chem. 2010. PMID: 20378535 Free PMC article.
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.
Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, García-Rivera G, Orozco E, Martínez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, Reed SL. Debnath A, et al. Among authors: mckerrow jh. Nat Med. 2012 Jun;18(6):956-60. doi: 10.1038/nm.2758. Nat Med. 2012. PMID: 22610278 Free PMC article.
Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica.
Que X, Brinen LS, Perkins P, Herdman S, Hirata K, Torian BE, Rubin H, McKerrow JH, Reed SL. Que X, et al. Among authors: mckerrow jh. Mol Biochem Parasitol. 2002 Jan;119(1):23-32. doi: 10.1016/s0166-6851(01)00387-5. Mol Biochem Parasitol. 2002. PMID: 11755183
A phagocytosis mutant of Entamoeba histolytica is less virulent due to deficient proteinase expression and release.
Hirata KK, Que X, Melendez-Lopez SG, Debnath A, Myers S, Herdman DS, Orozco E, Bhattacharya A, McKerrow JH, Reed SL. Hirata KK, et al. Among authors: mckerrow jh. Exp Parasitol. 2007 Feb;115(2):192-9. doi: 10.1016/j.exppara.2006.08.004. Epub 2006 Sep 20. Exp Parasitol. 2007. PMID: 16987516
Partial characterization of the proteolytic secretions of Acanthamoeba polyphaga.
Mitro K, Bhagavathiammai A, Zhou OM, Bobbett G, McKerrow JH, Chokshi R, Chokshi B, James ER. Mitro K, et al. Among authors: mckerrow jh. Exp Parasitol. 1994 Jun;78(4):377-85. doi: 10.1006/expr.1994.1041. Exp Parasitol. 1994. PMID: 8206136
Thiol proteinase expression and pathogenicity of Entamoeba histolytica.
Reed SL, Keene WE, McKerrow JH. Reed SL, et al. Among authors: mckerrow jh. J Clin Microbiol. 1989 Dec;27(12):2772-7. doi: 10.1128/JCM.27.12.2772-2777.1989. J Clin Microbiol. 1989. PMID: 2556432 Free PMC article.
Cleavage of C3 by a neutral cysteine proteinase of Entamoeba histolytica.
Reed SL, Keene WE, McKerrow JH, Gigli I. Reed SL, et al. Among authors: mckerrow jh. J Immunol. 1989 Jul 1;143(1):189-95. J Immunol. 1989. PMID: 2543700
Entamoeba histolytica: correlation of the cytopathic effect of virulent trophozoites with secretion of a cysteine proteinase.
Keene WE, Hidalgo ME, Orozco E, McKerrow JH. Keene WE, et al. Among authors: mckerrow jh. Exp Parasitol. 1990 Aug;71(2):199-206. doi: 10.1016/0014-4894(90)90022-5. Exp Parasitol. 1990. PMID: 2373188
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