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The proteases and pathogenicity of parasitic protozoa.
McKerrow JH, Sun E, Rosenthal PJ, Bouvier J. McKerrow JH, et al. Annu Rev Microbiol. 1993;47:821-53. doi: 10.1146/annurev.mi.47.100193.004133. Annu Rev Microbiol. 1993. PMID: 8257117 Review.
Proteomic analysis of human skin treated with larval schistosome peptidases reveals distinct invasion strategies among species of blood flukes.
Ingram J, Knudsen G, Lim KC, Hansell E, Sakanari J, McKerrow J. Ingram J, et al. Among authors: mckerrow j. PLoS Negl Trop Dis. 2011 Sep;5(9):e1337. doi: 10.1371/journal.pntd.0001337. Epub 2011 Sep 27. PLoS Negl Trop Dis. 2011. PMID: 21980548 Free PMC article.
Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model.
Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Chen YT, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL Jr, Reed SL. Meléndez-López SG, et al. Among authors: mckerrow j. Eukaryot Cell. 2007 Jul;6(7):1130-6. doi: 10.1128/EC.00094-07. Epub 2007 May 18. Eukaryot Cell. 2007. PMID: 17513563 Free PMC article.
Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors.
Fajtová P, Štefanić S, Hradilek M, Dvořák J, Vondrášek J, Jílková A, Ulrychová L, McKerrow JH, Caffrey CR, Mareš M, Horn M. Fajtová P, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2015 Jun 3;9(6):e0003827. doi: 10.1371/journal.pntd.0003827. eCollection 2015. PLoS Negl Trop Dis. 2015. PMID: 26039195 Free PMC article.
Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria.
Goupil LS, Ivry SL, Hsieh I, Suzuki BM, Craik CS, O'Donoghue AJ, McKerrow JH. Goupil LS, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2016 Aug 8;10(8):e0004893. doi: 10.1371/journal.pntd.0004893. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27501047 Free PMC article.
Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.
Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. Debnath A, et al. Among authors: mckerrow jh. Antimicrob Agents Chemother. 2014 Jul;58(7):4138-44. doi: 10.1128/AAC.02576-14. Epub 2014 May 12. Antimicrob Agents Chemother. 2014. PMID: 24820073 Free PMC article.
A global comparison of the human and T. brucei degradomes gives insights about possible parasite drug targets.
Mashiyama ST, Koupparis K, Caffrey CR, McKerrow JH, Babbitt PC. Mashiyama ST, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2012;6(12):e1942. doi: 10.1371/journal.pntd.0001942. Epub 2012 Dec 6. PLoS Negl Trop Dis. 2012. PMID: 23236535 Free PMC article.
A parasite cysteine protease is key to host protein degradation and iron acquisition.
O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH. O'Brien TC, et al. Among authors: mckerrow jh. J Biol Chem. 2008 Oct 24;283(43):28934-43. doi: 10.1074/jbc.M805824200. Epub 2008 Aug 13. J Biol Chem. 2008. PMID: 18701454 Free PMC article.
Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.
Chen CK, Leung SS, Guilbert C, Jacobson MP, McKerrow JH, Podust LM. Chen CK, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2010 Apr 6;4(4):e651. doi: 10.1371/journal.pntd.0000651. PLoS Negl Trop Dis. 2010. PMID: 20386598 Free PMC article.
RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.
Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, McKerrow JH. Abdulla MH, et al. Among authors: mckerrow jh. PLoS Negl Trop Dis. 2008 Sep 24;2(9):e298. doi: 10.1371/journal.pntd.0000298. PLoS Negl Trop Dis. 2008. PMID: 18820745 Free PMC article.
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