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Brain cholinergic vulnerability: relevance to behavior and disease.
McKinney M, Jacksonville MC. McKinney M, et al. Biochem Pharmacol. 2005 Oct 15;70(8):1115-24. doi: 10.1016/j.bcp.2005.05.019. Biochem Pharmacol. 2005. PMID: 15975560 Review.
Hippocampal muscarinic receptor function in spatial learning-impaired aged rats.
Chouinard ML, Gallagher M, Yasuda RP, Wolfe BB, McKinney M. Chouinard ML, et al. Neurobiol Aging. 1995 Nov-Dec;16(6):955-63. doi: 10.1016/0197-4580(95)02015-2. Neurobiol Aging. 1995. PMID: 8622787
The dissociation constant (KD) for the agonist oxotremorine-M and the KD/EC50 ratio, an indicator of receptor-effector coupling efficiency were similar in young and aged rats. However, the maximal PI turnover response to oxotremorine-M was decreased in impaired aged …
The dissociation constant (KD) for the agonist oxotremorine-M and the KD/EC50 ratio, an indicator of receptor-effector coupling effic …
Delineating the pharmacophoric elements of huperzine A: importance of the unsaturated three-carbon bridge to its AChE inhibitory activity.
Kozikowski AP, Miller CP, Yamada F, Pang YP, Miller JH, McKinney M, Ball RG. Kozikowski AP, et al. J Med Chem. 1991 Dec;34(12):3399-402. doi: 10.1021/jm00116a010. J Med Chem. 1991. PMID: 1766006 No abstract available.
Pharmacological characterization of the novel cholinomimetic L-689,660 at cloned and native brain muscarinic receptors.
Aagaard P, McKinney M. Aagaard P, et al. J Pharmacol Exp Ther. 1993 Dec;267(3):1478-83. J Pharmacol Exp Ther. 1993. PMID: 8263809
For stimulation of phosphoinositide turnover in rat cortical and hippocampal dissociated tissue, L-689,660 was a partial agonist (24% and 26% intrinsic activity, respectively, relative to oxotremorine-M) with EC50 values of 71 microM and 118 microM, respectively. ...L-689, …
For stimulation of phosphoinositide turnover in rat cortical and hippocampal dissociated tissue, L-689,660 was a partial agonist (24% and 26 …
Synthesis and in vitro characterization of novel amino terminally modified oxotremorine derivatives for brain muscarinic receptors.
Garvey DS, Wasicak JT, Chung JY, Shue YK, Carrera GM, May PD, McKinney MM, Anderson D, Cadman E, Vella-Rountree L, et al. Garvey DS, et al. J Med Chem. 1992 May 1;35(9):1550-7. doi: 10.1021/jm00087a008. J Med Chem. 1992. PMID: 1578480
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