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Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.
Kokkonda S, Deng X, White KL, El Mazouni F, White J, Shackleford DM, Katneni K, Chiu FCK, Barker H, McLaren J, Crighton E, Chen G, Angulo-Barturen I, Jimenez-Diaz MB, Ferrer S, Huertas-Valentin L, Martinez-Martinez MS, Lafuente-Monasterio MJ, Chittimalla R, Shahi SP, Wittlin S, Waterson D, Burrows JN, Matthews D, Tomchick D, Rathod PK, Palmer MJ, Charman SA, Phillips MA. Kokkonda S, et al. Among authors: mclaren j. J Med Chem. 2020 May 14;63(9):4929-4956. doi: 10.1021/acs.jmedchem.0c00311. Epub 2020 Apr 16. J Med Chem. 2020. PMID: 32248693 Free PMC article.
Novel inhibitors of Plasmodium falciparum based on 2,5-disubstituted furans.
Krake SH, Martinez PDG, McLaren J, Ryan E, Chen G, White K, Charman SA, Campbell S, Willis P, Dias LC. Krake SH, et al. Among authors: mclaren j. Eur J Med Chem. 2017 Jan 27;126:929-936. doi: 10.1016/j.ejmech.2016.12.024. Epub 2016 Dec 11. Eur J Med Chem. 2017. PMID: 28002775
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439.
Shackleford DM, Chiu FCK, Katneni K, Blundell S, McLaren J, Wang X, Zhou L, Sriraghavan K, Alker AM, Hunziker D, Scheurer C, Zhao Q, Dong Y, Möhrle JJ, Abla N, Matile H, Wittlin S, Vennerstrom JL, Charman SA. Shackleford DM, et al. Among authors: mclaren j. ACS Infect Dis. 2021 Jul 9;7(7):1885-1893. doi: 10.1021/acsinfecdis.1c00225. Epub 2021 Jun 8. ACS Infect Dis. 2021. PMID: 34101429 Free PMC article.
Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12).
Dong Y, Sonawane Y, Maher SP, Zeeman AM, Chaumeau V, Vantaux A, Cooper CA, Chiu FCK, Ryan E, McLaren J, Chen G, Wittlin S, Witkowski B, Nosten F, Sriraghavan K, Kyle DE, Kocken CHM, Charman SA, Vennerstrom JL. Dong Y, et al. Among authors: mclaren j. ACS Omega. 2022 Mar 30;7(14):12401-12411. doi: 10.1021/acsomega.2c01099. eCollection 2022 Apr 12. ACS Omega. 2022. PMID: 35449901 Free PMC article.
Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin.
Pass M, Bolton RE, Coote SJ, Finch H, Hindley S, Lowdon A, McDonald E, McLaren J, Owen M, Pegg NA, Mooney CJ, Tang CM, Parry S, Patel C. Pass M, et al. Among authors: mclaren j. Bioorg Med Chem Lett. 1999 Feb 8;9(3):431-6. doi: 10.1016/s0960-894x(99)00002-5. Bioorg Med Chem Lett. 1999. PMID: 10091697
Imprecision of high-sensitivity cardiac troponin assays at the female 99th-percentile.
Kavsak PA, Clark L, Arnoldo S, Lou A, Shea JL, Eintracht S, Lyon AW, Bhayana V, Thorlacius L, Raizman JE, Tsui A, Djiana R, Chen M, Huang Y, Haider A, Booth RA, McCudden C, Yip PM, Beriault D, Blank D, Fung AWS, Taher J, St-Cyr J, Sharif S, Belley-Cote E, Abramson BL, Friedman SM, Cox JL, Sivilotti MLA, Chen-Tournoux A, McLaren J, Mak S, Thiruganasambandamoorthy V, Scheuermeyer F, Humphries KH, Worster A, Ko D, Aakre KM, Mills NL, Jaffe AS. Kavsak PA, et al. Among authors: mclaren j. Clin Biochem. 2024 Mar;125:110731. doi: 10.1016/j.clinbiochem.2024.110731. Epub 2024 Feb 13. Clin Biochem. 2024. PMID: 38360198 Free article.
564 results