McLean P - Search Results

1

Low-density lipoprotein receptor-related protein 1 (LRP1) regulates the stability and function of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor in neurons.

Gan M, Jiang P, McLean P, Kanekiyo T, Bu G. Gan M, et al. Among authors: mclean p. PLoS One. 2014 Dec 12;9(12):e113237. doi: 10.1371/journal.pone.0113237. eCollection 2014. PLoS One. 2014. PMID: 25500815 Free PMC article.

2

Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction.

Gan M, Moussaud S, Jiang P, McLean PJ. Gan M, et al. Among authors: mclean pj. Neurobiol Aging. 2015 Feb;36(2):1209-20. doi: 10.1016/j.neurobiolaging.2014.10.037. Epub 2014 Nov 5. Neurobiol Aging. 2015. PMID: 25480524 Free PMC article.

3

Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons.

Jiang P, Gan M, Yen SH, Moussaud S, McLean PJ, Dickson DW. Jiang P, et al. Among authors: mclean pj. Acta Neuropathol. 2016 Jul;132(1):77-91. doi: 10.1007/s00401-016-1542-4. Epub 2016 Feb 2. Acta Neuropathol. 2016. PMID: 26839082 Free PMC article.

4

Histones facilitate α-synuclein aggregation during neuronal apoptosis.

Jiang P, Gan M, Yen SH, McLean PJ, Dickson DW. Jiang P, et al. Among authors: mclean pj. Acta Neuropathol. 2017 Apr;133(4):547-558. doi: 10.1007/s00401-016-1660-z. Epub 2016 Dec 21. Acta Neuropathol. 2017. PMID: 28004278 Free PMC article.

5

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates.

Jiang P, Gan M, Yen SH, McLean PJ, Dickson DW. Jiang P, et al. Among authors: mclean pj. Sci Rep. 2017 Aug 9;7(1):7690. doi: 10.1038/s41598-017-08149-w. Sci Rep. 2017. PMID: 28794446 Free PMC article.

6

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid.

Zhao N, Attrebi ON, Ren Y, Qiao W, Sonustun B, Martens YA, Meneses AD, Li F, Shue F, Zheng J, Van Ingelgom AJ, Davis MD, Kurti A, Knight JA, Linares C, Chen Y, Delenclos M, Liu CC, Fryer JD, Asmann YW, McLean PJ, Dickson DW, Ross OA, Bu G. Zhao N, et al. Sci Transl Med. 2020 Feb 5;12(529):eaay1809. doi: 10.1126/scitranslmed.aay1809. Sci Transl Med. 2020. PMID: 32024798 Free PMC article.

7

APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology.

Jin Y, Li F, Sonoustoun B, Kondru NC, Martens YA, Qiao W, Heckman MG, Ikezu TC, Li Z, Burgess JD, Amerna D, O'Leary J, DeTure MA, Zhao J, McLean PJ, Dickson DW, Ross OA, Bu G, Zhao N. Jin Y, et al. Acta Neuropathol. 2022 Jun;143(6):641-662. doi: 10.1007/s00401-022-02421-8. Epub 2022 Apr 26. Acta Neuropathol. 2022. PMID: 35471463 Free PMC article.

8

Dopamine-induced conformational changes in alpha-synuclein.

Outeiro TF, Klucken J, Bercury K, Tetzlaff J, Putcha P, Oliveira LM, Quintas A, McLean PJ, Hyman BT. Outeiro TF, et al. Among authors: mclean pj. PLoS One. 2009 Sep 4;4(9):e6906. doi: 10.1371/journal.pone.0006906. PLoS One. 2009. PMID: 19730729 Free PMC article.

9

In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility.

Unni VK, Weissman TA, Rockenstein E, Masliah E, McLean PJ, Hyman BT. Unni VK, et al. PLoS One. 2010 May 11;5(5):e10589. doi: 10.1371/journal.pone.0010589. PLoS One. 2010. PMID: 20485674 Free PMC article.

10

Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics.

Dimant H, Zhu L, Kibuuka LN, Fan Z, Hyman BT, McLean PJ. Dimant H, et al. PLoS One. 2014 Mar 24;9(3):e92098. doi: 10.1371/journal.pone.0092098. eCollection 2014. PLoS One. 2014. PMID: 24664141 Free PMC article.

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