McLean PJ - Search Results

1

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.

Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ. Outeiro TF, et al. Among authors: mclean pj. Biochem Biophys Res Commun. 2006 Dec 22;351(3):631-8. doi: 10.1016/j.bbrc.2006.10.085. Epub 2006 Oct 26. Biochem Biophys Res Commun. 2006. PMID: 17081499 Free PMC article.

2

Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies.

Klucken J, Ingelsson M, Shin Y, Irizarry MC, Hedley-Whyte ET, Frosch M, Growdon J, McLean P, Hyman BT. Klucken J, et al. Acta Neuropathol. 2006 Feb;111(2):101-8. doi: 10.1007/s00401-005-0027-7. Epub 2006 Feb 16. Acta Neuropathol. 2006. PMID: 16482476

3

An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation.

McLean PJ, Hyman BT. McLean PJ, et al. Neurosci Lett. 2002 May 3;323(3):219-23. doi: 10.1016/s0304-3940(02)00154-4. Neurosci Lett. 2002. PMID: 11959424

4

TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation.

McLean PJ, Kawamata H, Shariff S, Hewett J, Sharma N, Ueda K, Breakefield XO, Hyman BT. McLean PJ, et al. J Neurochem. 2002 Nov;83(4):846-54. doi: 10.1046/j.1471-4159.2002.01190.x. J Neurochem. 2002. PMID: 12421356 Free article.

5

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.

Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ. Klucken J, et al. Among authors: mclean pj. J Biol Chem. 2004 Jun 11;279(24):25497-502. doi: 10.1074/jbc.M400255200. Epub 2004 Mar 25. J Biol Chem. 2004. PMID: 15044495 Free article.

6

Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.

McLean PJ, Klucken J, Shin Y, Hyman BT. McLean PJ, et al. Biochem Biophys Res Commun. 2004 Aug 27;321(3):665-9. doi: 10.1016/j.bbrc.2004.07.021. Biochem Biophys Res Commun. 2004. PMID: 15358157

7

A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.

Klucken J, Shin Y, Hyman BT, McLean PJ. Klucken J, et al. Among authors: mclean pj. Biochem Biophys Res Commun. 2004 Dec 3;325(1):367-73. doi: 10.1016/j.bbrc.2004.10.037. Biochem Biophys Res Commun. 2004. PMID: 15522241

8

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.

Shin Y, Klucken J, Patterson C, Hyman BT, McLean PJ. Shin Y, et al. Among authors: mclean pj. J Biol Chem. 2005 Jun 24;280(25):23727-34. doi: 10.1074/jbc.M503326200. Epub 2005 Apr 21. J Biol Chem. 2005. PMID: 15845543 Free article.

9

Alpha-synuclein and chaperones in dementia with Lewy bodies.

Cantuti-Castelvetri I, Klucken J, Ingelsson M, Ramasamy K, McLean PJ, Frosch MP, Hyman BT, Standaert DG. Cantuti-Castelvetri I, et al. Among authors: mclean pj. J Neuropathol Exp Neurol. 2005 Dec;64(12):1058-66. doi: 10.1097/01.jnen.0000190063.90440.69. J Neuropathol Exp Neurol. 2005. PMID: 16319716

10

Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging.

Klucken J, Outeiro TF, Nguyen P, McLean PJ, Hyman BT. Klucken J, et al. Among authors: mclean pj. FASEB J. 2006 Oct;20(12):2050-7. doi: 10.1096/fj.05-5422com. FASEB J. 2006. PMID: 17012257

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