McLean PJ - Search Results

1

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.

Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG. Outeiro TF, et al. Among authors: mclean pj. Science. 2007 Jul 27;317(5837):516-9. doi: 10.1126/science.1143780. Epub 2007 Jun 21. Science. 2007. PMID: 17588900

2

An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation.

McLean PJ, Hyman BT. McLean PJ, et al. Neurosci Lett. 2002 May 3;323(3):219-23. doi: 10.1016/s0304-3940(02)00154-4. Neurosci Lett. 2002. PMID: 11959424

3

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.

Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ. Klucken J, et al. Among authors: mclean pj. J Biol Chem. 2004 Jun 11;279(24):25497-502. doi: 10.1074/jbc.M400255200. Epub 2004 Mar 25. J Biol Chem. 2004. PMID: 15044495 Free article.

4

A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.

Klucken J, Shin Y, Hyman BT, McLean PJ. Klucken J, et al. Among authors: mclean pj. Biochem Biophys Res Commun. 2004 Dec 3;325(1):367-73. doi: 10.1016/j.bbrc.2004.10.037. Biochem Biophys Res Commun. 2004. PMID: 15522241

5

Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging.

Klucken J, Outeiro TF, Nguyen P, McLean PJ, Hyman BT. Klucken J, et al. Among authors: mclean pj. FASEB J. 2006 Oct;20(12):2050-7. doi: 10.1096/fj.05-5422com. FASEB J. 2006. PMID: 17012257

6

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.

Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ. Outeiro TF, et al. Among authors: mclean pj. Biochem Biophys Res Commun. 2006 Dec 22;351(3):631-8. doi: 10.1016/j.bbrc.2006.10.085. Epub 2006 Oct 26. Biochem Biophys Res Commun. 2006. PMID: 17081499 Free PMC article.

7

Dopamine-induced conformational changes in alpha-synuclein.

Outeiro TF, Klucken J, Bercury K, Tetzlaff J, Putcha P, Oliveira LM, Quintas A, McLean PJ, Hyman BT. Outeiro TF, et al. Among authors: mclean pj. PLoS One. 2009 Sep 4;4(9):e6906. doi: 10.1371/journal.pone.0006906. PLoS One. 2009. PMID: 19730729 Free PMC article.

8

Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.

McLean PJ, Klucken J, Shin Y, Hyman BT. McLean PJ, et al. Biochem Biophys Res Commun. 2004 Aug 27;321(3):665-9. doi: 10.1016/j.bbrc.2004.07.021. Biochem Biophys Res Commun. 2004. PMID: 15358157

9

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.

Shin Y, Klucken J, Patterson C, Hyman BT, McLean PJ. Shin Y, et al. Among authors: mclean pj. J Biol Chem. 2005 Jun 24;280(25):23727-34. doi: 10.1074/jbc.M503326200. Epub 2005 Apr 21. J Biol Chem. 2005. PMID: 15845543 Free article.

10

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.

Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG. Bodner RA, et al. Among authors: mclean pj. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4246-51. doi: 10.1073/pnas.0511256103. Epub 2006 Mar 6. Proc Natl Acad Sci U S A. 2006. PMID: 16537516 Free PMC article.

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