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992 results
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Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242).
Verhoest PR, Basak AS, Parikh V, Hayward M, Kauffman GW, Paradis V, McHardy SF, McLean S, Grimwood S, Schmidt AW, Vanase-Frawley M, Freeman J, Van Deusen J, Cox L, Wong D, Liras S. Verhoest PR, et al. Among authors: mclean s. J Med Chem. 2011 Aug 25;54(16):5868-77. doi: 10.1021/jm2006035. Epub 2011 Jul 22. J Med Chem. 2011. PMID: 21744827
Biaryl piperidines as potent and selective delta opioid receptor ligands.
Liras S, McHardy SF, Allen MP, Segelstein BE, Heck SD, Bryce DK, Schmidt AW, Vanase-Frawley M, Callegari E, McLean S. Liras S, et al. Among authors: mclean s. Bioorg Med Chem Lett. 2010 Jan 15;20(2):503-7. doi: 10.1016/j.bmcl.2009.11.113. Epub 2009 Nov 26. Bioorg Med Chem Lett. 2010. PMID: 20015649
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.
O'Donnell CJ, Rogers BN, Bronk BS, Bryce DK, Coe JW, Cook KK, Duplantier AJ, Evrard E, Hajós M, Hoffmann WE, Hurst RS, Maklad N, Mather RJ, McLean S, Nedza FM, O'Neill BT, Peng L, Qian W, Rottas MM, Sands SB, Schmidt AW, Shrikhande AV, Spracklin DK, Wong DF, Zhang A, Zhang L. O'Donnell CJ, et al. Among authors: mclean s. J Med Chem. 2010 Feb 11;53(3):1222-37. doi: 10.1021/jm9015075. J Med Chem. 2010. PMID: 20043678
Aza-tricyclic substance P antagonists.
Lowe JA 3rd, Drozda SE, McLean S, Bryce DK, Crawford RT, Snider RM, Longo KP, Nagahisa A, Tsuchiya M. Lowe JA 3rd, et al. Among authors: mclean s. J Med Chem. 1994 Sep 2;37(18):2831-40. doi: 10.1021/jm00044a002. J Med Chem. 1994. PMID: 7520943
Nonpeptide antagonists of the NK1 tachykinin receptor.
McLean S. McLean S. Med Res Rev. 1996 Jul;16(4):297-317. doi: 10.1002/(SICI)1098-1128(199607)16:4<297::AID-MED1>3.0.CO;2-S. Med Res Rev. 1996. PMID: 8798177 Review. No abstract available.
Synthesis, in vitro binding profile, and autoradiographic analysis of [3H]-cis-3-[(2-methoxybenzyl)amino]-2-phenylpiperidine, a highly potent and selective nonpeptide substance P receptor antagonist radioligand.
Rosen T, Seeger TF, McLean S, Desai MC, Guarino KJ, Bryce D, Pratt K, Heym J, Chalabi PM, Windels JH, et al. Rosen T, et al. Among authors: mclean s. J Med Chem. 1993 Oct 15;36(21):3197-201. doi: 10.1021/jm00073a022. J Med Chem. 1993. PMID: 7693945
992 results