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A genetic basis for the variable effect of smoking/nicotine on Parkinson's disease.
Pharmacogenomics J. 2013 Dec;13(6):530-7. doi: 10.1038/tpj.2012.38. Epub 2012 Oct 2.
Pharmacogenomics J. 2013.
PMID: 23032990
Free PMC article.
Combinational approach of intrabody with enhanced Hsp70 expression addresses multiple pathologies in a fly model of Huntington's disease.
McLear JA, Lebrecht D, Messer A, Wolfgang WJ.
McLear JA, et al.
FASEB J. 2008 Jun;22(6):2003-11. doi: 10.1096/fj.07-099689. Epub 2008 Jan 16.
FASEB J. 2008.
PMID: 18199697
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Cystamine and intrabody co-treatment confers additional benefits in a fly model of Huntington's disease.
Bortvedt SF, McLear JA, Messer A, Ahern-Rindell AJ, Wolfgang WJ.
Bortvedt SF, et al. Among authors: mclear ja.
Neurobiol Dis. 2010 Oct;40(1):130-4. doi: 10.1016/j.nbd.2010.04.007. Epub 2010 Apr 24.
Neurobiol Dis. 2010.
PMID: 20399860
Free PMC article.
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The therapeutic potential of intrabodies in neurologic disorders: focus on Huntington and Parkinson diseases.
Messer A, McLear J.
Messer A, et al.
BioDrugs. 2006;20(6):327-33. doi: 10.2165/00063030-200620060-00002.
BioDrugs. 2006.
PMID: 17176119
Review.
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Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteins.
Butler DC, McLear JA, Messer A.
Butler DC, et al. Among authors: mclear ja.
Prog Neurobiol. 2012 May;97(2):190-204. doi: 10.1016/j.pneurobio.2011.11.004. Epub 2011 Nov 18.
Prog Neurobiol. 2012.
PMID: 22120646
Free PMC article.
Review.
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Early or late-stage anti-N-terminal Huntingtin intrabody gene therapy reduces pathological features in B6.HDR6/1 mice.
Snyder-Keller A, McLear JA, Hathorn T, Messer A.
Snyder-Keller A, et al. Among authors: mclear ja.
J Neuropathol Exp Neurol. 2010 Oct;69(10):1078-85. doi: 10.1097/NEN.0b013e3181f530ec.
J Neuropathol Exp Neurol. 2010.
PMID: 20838238
Free PMC article.
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In vivo inactivation of pRb, p107 and p130 in murine neuroprogenitor cells leads to major CNS developmental defects and high seizure rates.
McLear JA, Garcia-Fresco G, Bhat MA, Van Dyke TA.
McLear JA, et al.
Mol Cell Neurosci. 2006 Nov;33(3):260-73. doi: 10.1016/j.mcn.2006.07.012. Epub 2006 Sep 18.
Mol Cell Neurosci. 2006.
PMID: 16979903
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