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Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance.
McFadyen MC, McLeod HL, Jackson FC, Melvin WT, Doehmer J, Murray GI. McFadyen MC, et al. Among authors: mcleod hl. Biochem Pharmacol. 2001 Jul 15;62(2):207-12. doi: 10.1016/s0006-2952(01)00643-8. Biochem Pharmacol. 2001. PMID: 11389879
A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity.
Fukami T, Nakajima M, Higashi E, Yamanaka H, McLeod HL, Yokoi T. Fukami T, et al. Among authors: mcleod hl. Biochem Pharmacol. 2005 Sep 1;70(5):801-8. doi: 10.1016/j.bcp.2005.05.029. Biochem Pharmacol. 2005. PMID: 15993850
MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity.
Ameyaw MM, Regateiro F, Li T, Liu X, Tariq M, Mobarek A, Thornton N, Folayan GO, Githang'a J, Indalo A, Ofori-Adjei D, Price-Evans DA, McLeod HL. Ameyaw MM, et al. Among authors: mcleod hl. Pharmacogenetics. 2001 Apr;11(3):217-21. doi: 10.1097/00008571-200104000-00005. Pharmacogenetics. 2001. PMID: 11337937
Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.
Wang W, McLeod HL, Cassidy J, Collie-Duguid ES. Wang W, et al. Among authors: mcleod hl. Cancer Chemother Pharmacol. 2007 May;59(6):839-45. doi: 10.1007/s00280-006-0384-5. Epub 2006 Nov 22. Cancer Chemother Pharmacol. 2007. PMID: 17119966
Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines.
Wang W, McLeod HL, Cassidy J. Wang W, et al. Among authors: mcleod hl. Int J Cancer. 2003 Apr 20;104(4):504-11. doi: 10.1002/ijc.10972. Int J Cancer. 2003. PMID: 12584750
Topoisomerase I protein expression in primary colorectal cancer and lymph node metastases.
Boonsong A, Curran S, McKay JA, Cassidy J, Murray GI, McLeod HL. Boonsong A, et al. Among authors: mcleod hl. Hum Pathol. 2002 Nov;33(11):1114-9. doi: 10.1053/hupa.2002.129202. Hum Pathol. 2002. PMID: 12454816
Analysis of key cell-cycle checkpoint proteins in colorectal tumours.
McKay JA, Douglas JJ, Ross VG, Curran S, Loane JF, Ahmed FY, Cassidy J, McLeod HL, Murray GI. McKay JA, et al. Among authors: mcleod hl. J Pathol. 2002 Apr;196(4):386-93. doi: 10.1002/path.1053. J Pathol. 2002. PMID: 11920733
Evaluation of dihydropyrimidine dehydrogenase activity in South-west Asian, Kenyan and Ghanaian populations.
Morsman JM, Sludden J, Ameyaw MM, Githang'A J, Indalo A, Ofori-Adjei D, McLeod HL. Morsman JM, et al. Among authors: mcleod hl. Br J Clin Pharmacol. 2000 Sep;50(3):269-72. doi: 10.1046/j.1365-2125.2000.00242.x. Br J Clin Pharmacol. 2000. PMID: 10971312 Free PMC article.
Cloning and initial characterization of the human DPYD gene promoter.
Collie-Duguid ES, Johnston SJ, Powrie RH, Milano G, Etienne MC, Rochat B, Watson GC, McLeod HL. Collie-Duguid ES, et al. Among authors: mcleod hl. Biochem Biophys Res Commun. 2000 Apr 29;271(1):28-35. doi: 10.1006/bbrc.2000.2593. Biochem Biophys Res Commun. 2000. PMID: 10777676
Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.
Ridge SA, Sludden J, Brown O, Robertson L, Wei X, Sapone A, Fernandez-Salguero PM, Gonzalez FJ, Vreken P, van Kuilenburg AB, van Gennip AH, McLeod HL. Ridge SA, et al. Among authors: mcleod hl. Br J Clin Pharmacol. 1998 Aug;46(2):151-6. doi: 10.1046/j.1365-2125.1998.00751.x. Br J Clin Pharmacol. 1998. PMID: 9723824 Free PMC article.
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