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Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.
Chowdhry S, Zhang Y, McMahon M, Sutherland C, Cuadrado A, Hayes JD. Chowdhry S, et al. Oncogene. 2013 Aug 8;32(32):3765-81. doi: 10.1038/onc.2012.388. Epub 2012 Sep 10. Oncogene. 2013. PMID: 22964642 Free PMC article.
The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.
Hayes JD, Chanas SA, Henderson CJ, McMahon M, Sun C, Moffat GJ, Wolf CR, Yamamoto M. Hayes JD, et al. Biochem Soc Trans. 2000 Feb;28(2):33-41. doi: 10.1042/bst0280033. Biochem Soc Trans. 2000. PMID: 10816095
The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
McMahon M, Itoh K, Yamamoto M, Chanas SA, Henderson CJ, McLellan LI, Wolf CR, Cavin C, Hayes JD. McMahon M, et al. Cancer Res. 2001 Apr 15;61(8):3299-307. Cancer Res. 2001. PMID: 11309284
SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.
Rada P, Rojo AI, Chowdhry S, McMahon M, Hayes JD, Cuadrado A. Rada P, et al. Mol Cell Biol. 2011 Mar;31(6):1121-33. doi: 10.1128/MCB.01204-10. Epub 2011 Jan 18. Mol Cell Biol. 2011. PMID: 21245377 Free PMC article.
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD. McMahon M, et al. J Biol Chem. 2006 Aug 25;281(34):24756-68. doi: 10.1074/jbc.M601119200. Epub 2006 Jun 21. J Biol Chem. 2006. PMID: 16790436
Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.
Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT. Hayes JD, et al. Antioxid Redox Signal. 2010 Dec 1;13(11):1713-48. doi: 10.1089/ars.2010.3221. Epub 2010 Aug 14. Antioxid Redox Signal. 2010. PMID: 20446772 Review.
1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein.
Kelleher MO, McMahon M, Eggleston IM, Dixon MJ, Taguchi K, Yamamoto M, Hayes JD. Kelleher MO, et al. Carcinogenesis. 2009 Oct;30(10):1754-62. doi: 10.1093/carcin/bgp182. Epub 2009 Jul 24. Carcinogenesis. 2009. PMID: 19633057
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