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15 results
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The hERG potassium channel and hERG screening for drug-induced torsades de pointes.
Hancox JC, McPate MJ, El Harchi A, Zhang YH. Hancox JC, et al. Among authors: mcpate mj. Pharmacol Ther. 2008 Aug;119(2):118-32. doi: 10.1016/j.pharmthera.2008.05.009. Epub 2008 Jun 18. Pharmacol Ther. 2008. PMID: 18616963 Review.
Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform.
Du CY, El Harchi A, McPate MJ, Orchard CH, Hancox JC. Du CY, et al. Among authors: mcpate mj. Biochem Biophys Res Commun. 2011 Feb 11;405(2):222-7. doi: 10.1016/j.bbrc.2011.01.014. Epub 2011 Jan 8. Biochem Biophys Res Commun. 2011. PMID: 21219869
Action potential clamp and mefloquine sensitivity of recombinant 'I KS' channels incorporating the V307L KCNQ1 mutation.
El Harchi A, McPate MJ, Zhang YH, Zhang H, Hancox JC. El Harchi A, et al. Among authors: mcpate mj. J Physiol Pharmacol. 2010 Apr;61(2):123-31. J Physiol Pharmacol. 2010. PMID: 20436212 Free article.
hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome.
McPate MJ, Zhang H, Cordeiro JM, Dempsey CE, Witchel HJ, Hancox JC. McPate MJ, et al. Biochem Biophys Res Commun. 2009 Aug 14;386(1):111-7. doi: 10.1016/j.bbrc.2009.05.134. Epub 2009 Jun 6. Biochem Biophys Res Commun. 2009. PMID: 19501051 Free PMC article.
Comparative effects of the short QT N588K mutation at 37 degrees C on hERG K+ channel current during ventricular, Purkinje fibre and atrial action potentials: an action potential clamp study.
McPate MJ, Zhang H, Adeniran I, Cordeiro JM, Witchel HJ, Hancox JC. McPate MJ, et al. J Physiol Pharmacol. 2009 Mar;60(1):23-41. J Physiol Pharmacol. 2009. PMID: 19439805 Free article.
Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin.
Duncan RS, McPate MJ, Ridley JM, Gao Z, James AF, Leishman DJ, Leaney JL, Witchel HJ, Hancox JC. Duncan RS, et al. Among authors: mcpate mj. Biochem Pharmacol. 2007 Aug 1;74(3):425-37. doi: 10.1016/j.bcp.2007.04.024. Epub 2007 May 3. Biochem Pharmacol. 2007. PMID: 17560554 Free PMC article.
Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs.
McPate MJ, Duncan RS, Hancox JC, Witchel HJ. McPate MJ, et al. Br J Pharmacol. 2008 Nov;155(6):957-66. doi: 10.1038/bjp.2008.325. Epub 2008 Aug 25. Br J Pharmacol. 2008. PMID: 18724381 Free PMC article.
Short QT syndrome.
McPate MJ, Witchel HJ, Hancox JC. McPate MJ, et al. Future Cardiol. 2006 May;2(3):293-301. doi: 10.2217/14796678.2.3.293. Future Cardiol. 2006. PMID: 19804087
Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome.
El Harchi A, McPate MJ, Zhang Yh, Zhang H, Hancox JC. El Harchi A, et al. Among authors: mcpate mj. J Mol Cell Cardiol. 2009 Nov;47(5):743-7. doi: 10.1016/j.yjmcc.2009.02.027. Epub 2009 Mar 10. J Mol Cell Cardiol. 2009. PMID: 19285083 Free PMC article.
Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome.
McPate MJ, Duncan RS, Witchel HJ, Hancox JC. McPate MJ, et al. J Mol Cell Cardiol. 2006 Sep;41(3):563-6. doi: 10.1016/j.yjmcc.2006.05.021. Epub 2006 Jul 12. J Mol Cell Cardiol. 2006. PMID: 16842817
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