McPhee F - Search Results

1

The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease.

Rutenber EE, De Voss JJ, Hoffman L, Stroud RM, Lee KH, Alvarez J, McPhee F, Craik C, Ortiz de Montellano PR. Rutenber EE, et al. Among authors: mcphee f. Bioorg Med Chem. 1997 Jul;5(7):1311-20. doi: 10.1016/s0968-0896(97)00078-3. Bioorg Med Chem. 1997. PMID: 9377091

2

A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere.

Rutenber EE, McPhee F, Kaplan AP, Gallion SL, Hogan JC Jr, Craik CS, Stroud RM. Rutenber EE, et al. Among authors: mcphee f. Bioorg Med Chem. 1996 Sep;4(9):1545-58. doi: 10.1016/0968-0896(96)00147-2. Bioorg Med Chem. 1996. PMID: 8894111

3

Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor.

Caldera PS, Yu Z, Knegtel RM, McPhee F, Burlingame AL, Craik CS, Kuntz ID, Ortiz de Montellano PR. Caldera PS, et al. Among authors: mcphee f. Bioorg Med Chem. 1997 Nov;5(11):2019-27. doi: 10.1016/s0968-0896(97)00131-4. Bioorg Med Chem. 1997. PMID: 9416419

4

Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation.

McPhee F, Good AC, Kuntz ID, Craik CS. McPhee F, et al. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11477-81. doi: 10.1073/pnas.93.21.11477. Proc Natl Acad Sci U S A. 1996. PMID: 8876160 Free PMC article.

5

Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro.

McPhee F, Caldera PS, Bemis GW, McDonagh AF, Kuntz ID, Craik CS. McPhee F, et al. Biochem J. 1996 Dec 1;320 ( Pt 2)(Pt 2):681-6. doi: 10.1042/bj3200681. Biochem J. 1996. PMID: 8973584 Free PMC article.

6

Optimization of a macromolecular inhibitor of HIV-1 protease.

Dauber DS, McPhee F, Unal A, Craik CS. Dauber DS, et al. Among authors: mcphee f. Adv Exp Med Biol. 1998;436:65-70. doi: 10.1007/978-1-4615-5373-1_9. Adv Exp Med Biol. 1998. PMID: 9561201 No abstract available.

7

Engineering catalytically defective forms of HIV protease to modulate its activity.

Craik CS, Babé LM, Dauber D, McPhee F, Rosé J, Unal A. Craik CS, et al. Among authors: mcphee f. Adv Exp Med Biol. 1998;436:31-9. doi: 10.1007/978-1-4615-5373-1_4. Adv Exp Med Biol. 1998. PMID: 9561196 Review. No abstract available.

8

Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.

Junker U, Escaich S, Plavec I, Baker J, McPhee F, Rose JR, Craik CS, Böhnlein E. Junker U, et al. Among authors: mcphee f. J Virol. 1996 Nov;70(11):7765-72. doi: 10.1128/JVI.70.11.7765-7772.1996. J Virol. 1996. PMID: 8892897 Free PMC article.

9

Structure-activity relationship studies of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of HCV NS3 serine protease.

Yeung KS, Meanwell NA, Qiu Z, Hernandez D, Zhang S, McPhee F, Weinheimer S, Clark JM, Janc JW. Yeung KS, et al. Among authors: mcphee f. Bioorg Med Chem Lett. 2001 Sep 3;11(17):2355-9. doi: 10.1016/s0960-894x(01)00457-7. Bioorg Med Chem Lett. 2001. PMID: 11527730

10

Discovery and early clinical evaluation of BMS-605339, a potent and orally efficacious tripeptidic acylsulfonamide NS3 protease inhibitor for the treatment of hepatitis C virus infection.

Scola PM, Wang AX, Good AC, Sun LQ, Combrink KD, Campbell JA, Chen J, Tu Y, Sin N, Venables BL, Sit SY, Chen Y, Cocuzza A, Bilder DM, D'Andrea S, Zheng B, Hewawasam P, Ding M, Thuring J, Li J, Hernandez D, Yu F, Falk P, Zhai G, Sheaffer AK, Chen C, Lee MS, Barry D, Knipe JO, Li W, Han YH, Jenkins S, Gesenberg C, Gao Q, Sinz MW, Santone KS, Zvyaga T, Rajamani R, Klei HE, Colonno RJ, Grasela DM, Hughes E, Chien C, Adams S, Levesque PC, Li D, Zhu J, Meanwell NA, McPhee F. Scola PM, et al. Among authors: mcphee f. J Med Chem. 2014 Mar 13;57(5):1708-29. doi: 10.1021/jm401840s. Epub 2014 Feb 20. J Med Chem. 2014. PMID: 24555570

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