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Size is everything--large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects.
Pain. 1998 Dec;78(3):209-216. doi: 10.1016/S0304-3959(98)00140-7.
Pain. 1998.
PMID: 9870574
Single-patient data meta-analysis of 3453 postoperative patients: oral tramadol versus placebo, codeine and combination analgesics.
Moore AR, McQuay JH.
Moore AR, et al. Among authors: mcquay jh.
Pain. 1997 Feb;69(3):287-294. doi: 10.1016/S0304-3959(96)03291-5.
Pain. 1997.
PMID: 9085303
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