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In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.
McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD. McCahill A, et al. Among authors: mcsorley t. Cell Signal. 2005 Sep;17(9):1158-73. doi: 10.1016/j.cellsig.2005.04.003. Cell Signal. 2005. PMID: 15905070
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.
Mongillo M, McSorley T, Evellin S, Sood A, Lissandron V, Terrin A, Huston E, Hannawacker A, Lohse MJ, Pozzan T, Houslay MD, Zaccolo M. Mongillo M, et al. Among authors: mcsorley t. Circ Res. 2004 Jul 9;95(1):67-75. doi: 10.1161/01.RES.0000134629.84732.11. Epub 2004 Jun 3. Circ Res. 2004. PMID: 15178638
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.
Lygren B, Carlson CR, Santamaria K, Lissandron V, McSorley T, Litzenberg J, Lorenz D, Wiesner B, Rosenthal W, Zaccolo M, Taskén K, Klussmann E. Lygren B, et al. Among authors: mcsorley t. EMBO Rep. 2007 Nov;8(11):1061-7. doi: 10.1038/sj.embor.7401081. Epub 2007 Sep 28. EMBO Rep. 2007. PMID: 17901878 Free PMC article.
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.
Hundsrucker C, Krause G, Beyermann M, Prinz A, Zimmermann B, Diekmann O, Lorenz D, Stefan E, Nedvetsky P, Dathe M, Christian F, McSorley T, Krause E, McConnachie G, Herberg FW, Scott JD, Rosenthal W, Klussmann E. Hundsrucker C, et al. Among authors: mcsorley t. Biochem J. 2006 Jun 1;396(2):297-306. doi: 10.1042/BJ20051970. Biochem J. 2006. PMID: 16483255 Free PMC article.
36 results