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Zeptomole detection of a viral nucleic acid using a target-activated ribozyme.
Vaish NK, Jadhav VR, Kossen K, Pasko C, Andrews LE, McSwiggen JA, Polisky B, Seiwert SD. Vaish NK, et al. Among authors: mcswiggen ja. RNA. 2003 Sep;9(9):1058-72. doi: 10.1261/rna.5760703. RNA. 2003. PMID: 12923255 Free PMC article.
Chemically modified hammerhead ribozymes with improved catalytic rates.
Burgin AB Jr, Gonzalez C, Matulic-Adamic J, Karpeisky AM, Usman N, McSwiggen JA, Beigelman L. Burgin AB Jr, et al. Among authors: mcswiggen ja. Biochemistry. 1996 Nov 12;35(45):14090-7. doi: 10.1021/bi961264u. Biochemistry. 1996. PMID: 8916894
Characterization of nuclease-resistant ribozymes directed against hepatitis B virus RNA.
Morrissey DV, Lee PA, Johnson DA, Overly SL, McSwiggen JA, Beigelman L, Mokler VR, Maloney L, Vargeese C, Bowman K, O'Brien JT, Shaffer CS, Conrad A, Schmid P, Morrey JD, Macejak DG, Pavco PA, Blatt LM. Morrissey DV, et al. Among authors: mcswiggen ja. J Viral Hepat. 2002 Nov;9(6):411-8. doi: 10.1046/j.1365-2893.2002.00383.x. J Viral Hepat. 2002. PMID: 12431202
Quantitation of ribozyme target abundance by QCPCR.
Beaudry AA, McSwiggen JA. Beaudry AA, et al. Among authors: mcswiggen ja. Methods Mol Biol. 1997;74:325-39. doi: 10.1385/0-89603-389-9:325. Methods Mol Biol. 1997. PMID: 9204447 No abstract available.
Optimizing the cell efficacy of synthetic ribozymes. Site selection and chemical modifications of ribozymes targeting the proto-oncogene c-myb.
Jarvis TC, Wincott FE, Alby LJ, McSwiggen JA, Beigelman L, Gustofson J, DiRenzo A, Levy K, Arthur M, Matulic-Adamic J, Karpeisky A, Gonzalez C, Woolf TM, Usman N, Stinchcomb DT. Jarvis TC, et al. Among authors: mcswiggen ja. J Biol Chem. 1996 Nov 15;271(46):29107-12. doi: 10.1074/jbc.271.46.29107. J Biol Chem. 1996. PMID: 8910566 Free article.
Hammerhead ribozyme engineering.
Usman N, Beigelman L, McSwiggen JA. Usman N, et al. Among authors: mcswiggen ja. Curr Opin Struct Biol. 1996 Aug;6(4):527-33. doi: 10.1016/s0959-440x(96)80119-9. Curr Opin Struct Biol. 1996. PMID: 8794164 Review.
Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance.
Beigelman L, McSwiggen JA, Draper KG, Gonzalez C, Jensen K, Karpeisky AM, Modak AS, Matulic-Adamic J, DiRenzo AB, Haeberli P, et al. Beigelman L, et al. J Biol Chem. 1995 Oct 27;270(43):25702-8. doi: 10.1074/jbc.270.43.25702. J Biol Chem. 1995. PMID: 7592749
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