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The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination.
McVey M, Kaeberlein M, Tissenbaum HA, Guarente L. McVey M, et al. Genetics. 2001 Apr;157(4):1531-42. Genetics. 2001. PMID: 11290710 Free PMC article.
Double sgs1 srs2 mutants are viable but have a high stochastic rate of terminal G2/M arrest. This arrest can be suppressed by mutations in RAD51, RAD52, and RAD57, suggesting that the cell cycle defect in sgs1 srs2 mutants results from inappropriate homologous recombinatio …
Double sgs1 srs2 mutants are viable but have a high stochastic rate of terminal G2/M arrest. This arrest can be suppressed by mutatio …
Using yeast to discover the fountain of youth.
Kaeberlein M, McVey M, Guarente L. Kaeberlein M, et al. Sci Aging Knowledge Environ. 2001 Oct 3;2001(1):pe1. doi: 10.1126/sageke.2001.1.pe1. Sci Aging Knowledge Environ. 2001. PMID: 14602950 Review.
Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.
McVey M, Larocque JR, Adams MD, Sekelsky JJ. McVey M, et al. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15694-9. doi: 10.1073/pnas.0406157101. Epub 2004 Oct 22. Proc Natl Acad Sci U S A. 2004. PMID: 15501916 Free PMC article.
Multiple functions of Drosophila BLM helicase in maintenance of genome stability.
McVey M, Andersen SL, Broze Y, Sekelsky J. McVey M, et al. Genetics. 2007 Aug;176(4):1979-92. doi: 10.1534/genetics.106.070052. Epub 2007 May 16. Genetics. 2007. PMID: 17507683 Free PMC article.
Removal of the bloom syndrome DNA helicase extends the utility of imprecise transposon excision for making null mutations in Drosophila.
Witsell A, Kane DP, Rubin S, McVey M. Witsell A, et al. Genetics. 2009 Nov;183(3):1187-93. doi: 10.1534/genetics.109.108472. Epub 2009 Aug 17. Genetics. 2009. PMID: 19687136 Free PMC article.
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