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In vitro activities of three semisynthetic amide derivatives of teicoplanin, MDL 62208, MDL 62211, and MDL 62873.
Biavasco F, Lupidi R, Varaldo PE. Biavasco F, et al. Antimicrob Agents Chemother. 1992 Feb;36(2):331-8. doi: 10.1128/AAC.36.2.331. Antimicrob Agents Chemother. 1992. PMID: 1534977 Free PMC article.
MDL 62208, MDL 62211, and MDL 62873 are three semisynthetic amide derivatives of teicoplanin (MDL 62208 is an amide of teicoplanin aglycone, MDL 62211 is an amide of the teicoplanin A2 complex, and MDL 62873 is the corresponding derivative of peak A2-2 …
MDL 62208, MDL 62211, and MDL 62873 are three semisynthetic amide derivatives of teicoplanin (MDL 62208 is an amide of teicopl …
Antimicrobial activity of MDL 63,246, a new semisynthetic glycopeptide antibiotic.
Goldstein BP, Candiani G, Arain TM, Romanò G, Ciciliato I, Berti M, Abbondi M, Scotti R, Mainini M, Ripamonti F, et al. Goldstein BP, et al. Antimicrob Agents Chemother. 1995 Jul;39(7):1580-8. doi: 10.1128/AAC.39.7.1580. Antimicrob Agents Chemother. 1995. PMID: 7492108 Free PMC article.
It was more active in vitro against Staphylococcus aureus and coagulase-negative staphylococci than MDL 62,476, teicoplanin, and vancomycin and was more active than mideplanin (MDL 62,873) against some isolates. MDL 63,246 had excellent activity against streptococci and te …
It was more active in vitro against Staphylococcus aureus and coagulase-negative staphylococci than MDL 62,476, teicoplanin, and vancomycin …
In-vitro activity of vancomycin, teicoplanin, daptomycin, ramoplanin, MDL 62873 and other agents against staphylococci, enterococci and Clostridium difficile.
Bartoloni A, Colao MG, Orsi A, Dei R, Giganti E, Parenti F. Bartoloni A, et al. J Antimicrob Chemother. 1990 Nov;26(5):627-33. doi: 10.1093/jac/26.5.627. J Antimicrob Chemother. 1990. PMID: 1688341
The antimicrobial agents tested were vancomycin, teicoplanin, daptomycin, ramoplanin, MDL 62873, rifampicin and piperacillin, the latter limited to enterococci. ...Teicoplanin (MIC90 0.45 mg/l) was the most active agent against enterococci, followed by MDL …
The antimicrobial agents tested were vancomycin, teicoplanin, daptomycin, ramoplanin, MDL 62873, rifampicin and piperacillin, …
Activities of two new teicoplanin amide derivatives (MDL 62211 and MDL 62873) compared with activities of teicoplanin and vancomycin against 800 recent staphylococcal isolates from France and the United States.
Jones RN, Goldstein FW, Zhou XY. Jones RN, et al. Antimicrob Agents Chemother. 1991 Mar;35(3):584-6. doi: 10.1128/AAC.35.3.584. Antimicrob Agents Chemother. 1991. PMID: 1828137 Free PMC article.
MDL 62211 is the amide derivative of the teicoplanin complex and MDL 62873 is a more focused amide derivative of the teicoplanin A2-2 peak. ...Teicoplanin-resistant U.S. isolates were usually Staphylococcus haemolyticus (1.8% of all tested strains), for which MICs r …
MDL 62211 is the amide derivative of the teicoplanin complex and MDL 62873 is a more focused amide derivative of the teicoplan …
In vitro effects of novel glycopeptide antibiotics on the reactivity of the lipopolysaccharide (LPS) of S. minnesota R595.
Matera G, Berlinghieri MC, Barreca G, Focà A. Matera G, et al. New Microbiol. 1995 Jul;18(3):325-9. New Microbiol. 1995. PMID: 7553371
Four novel glycopeptide antibiotics, namely MDL 62708, MDL 63155, MDL 62827, MDL 62873 (mideplanin), plus teicoplanin, which differ in their chemical structure, were used to examine the relationship between the structure of glycopeptides and their LPS neutral …
Four novel glycopeptide antibiotics, namely MDL 62708, MDL 63155, MDL 62827, MDL 62873 (mideplanin), plus teicoplanin, …
In vitro activity of mersacidin (M87-1551), an investigational peptide antibiotic tested against gram-positive bloodstream isolates.
Barrett MS, Wenzel RP, Jones RN. Barrett MS, et al. Diagn Microbiol Infect Dis. 1992 Sep-Oct;15(7):641-4. doi: 10.1016/0732-8893(90)90043-u. Diagn Microbiol Infect Dis. 1992. PMID: 1424522
The minimum inhibitory concentration (MIC)90 for mersacidin was 8-32 times higher than vancomycin for staphylococci, 4-64 times higher for enterococci, and up to 32 times higher for other organisms tested. The MIC90 for MDL 62873, a comparison compound, was less tha …
The minimum inhibitory concentration (MIC)90 for mersacidin was 8-32 times higher than vancomycin for staphylococci, 4-64 times higher for e …
Biotransformations of lipoglycopeptides to obtain novel antibiotics.
Gandolfi R, Jovetic S, Marinelli F, Molinari F. Gandolfi R, et al. J Antibiot (Tokyo). 2007 Apr;60(4):265-71. doi: 10.1038/ja.2007.33. J Antibiot (Tokyo). 2007. PMID: 17456978
It is worth noting that the actinomycetes able to catalyze the deacylation of lipoglycopeptides are themselves producers of microbiologically active glycopeptides. Structurally related antibiotics (mideplanin and teicoplanin) were not transformed. Biotransformation conditi …
It is worth noting that the actinomycetes able to catalyze the deacylation of lipoglycopeptides are themselves producers of microbiologicall …
New insights into glycopeptide antibiotic binding to cell wall precursors using SPR and NMR spectroscopy.
Treviño J, Bayón C, Ardá A, Marinelli F, Gandolfi R, Molinari F, Jimenez-Barbero J, Hernáiz MJ. Treviño J, et al. Chemistry. 2014 Jun 10;20(24):7363-72. doi: 10.1002/chem.201303310. Epub 2014 May 7. Chemistry. 2014. PMID: 24805824 Free article.
Herein, studies of the interaction of teicoplanin, teicoplanin-like A40926, and of their semisynthetic derivatives (mideplanin, MDL63,246, dalbavancin) with peptide analogues of cell-wall precursors by NMR spectroscopy and surface plasmon resonance (SPR) are reported. ...
Herein, studies of the interaction of teicoplanin, teicoplanin-like A40926, and of their semisynthetic derivatives (mideplanin, MDL63 …
Antistaphylococcal and antienterococcal activity of the new teicoplanin amide derivative MDL 62873.
Qadri SM, Saldin H, Ueno Y. Qadri SM, et al. Chemotherapy. 1993;39(1):55-8. doi: 10.1159/000238974. Chemotherapy. 1993. PMID: 8444061
In vitro activity of MDL 62873 was compared with that of ampicillin, augmentin, erythromycin and vancomycin. All the isolates were completely inhibited by MDL 62873 at an MIC ranging between 0.25 and 8.0 micrograms/ml. ...
In vitro activity of MDL 62873 was compared with that of ampicillin, augmentin, erythromycin and vancomycin. All the isolates …
Antimicrobial susceptibilities of enterococci isolated from hospitalized patients.
Venditti M, Tarasi A, Gelfusa V, Nicastri E, Penni A, Martino P. Venditti M, et al. Antimicrob Agents Chemother. 1993 May;37(5):1190-2. doi: 10.1128/AAC.37.5.1190. Antimicrob Agents Chemother. 1993. PMID: 8517714 Free PMC article.
One hundred and one isolates of Enterococcus species isolated recently from hospitalized patients were evaluated in vitro for antibiotic susceptibility. Teicoplanin and mideplanin were the most active agents, followed by ramoplanin, vancomycin, ciprofloxacin, ampicillin, a …
One hundred and one isolates of Enterococcus species isolated recently from hospitalized patients were evaluated in vitro for antibiotic sus …
15 results