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Antibody-Drug Conjugates in the Pipeline for Treatment of Melanoma: Target and Pharmacokinetic Considerations.
Lami I, Wiemer AJ. Lami I, et al. Drugs R D. 2024 Jun;24(2):129-144. doi: 10.1007/s40268-024-00473-7. Epub 2024 Jul 1. Drugs R D. 2024. PMID: 38951479 Free PMC article. Review.
At the same time, conjugates such as AMT-253, targeting melanoma cell adhesion molecule, and mecbotamab vedotin targeting AXL receptor tyrosine kinase, are among the most exciting for melanoma treatment in the future....
At the same time, conjugates such as AMT-253, targeting melanoma cell adhesion molecule, and mecbotamab vedotin targeting AXL recepto …
Preclinical development of mecbotamab vedotin (BA3011), a novel, AXL-specific conditional active biologic antibody-drug conjugate.
Chang HW, Wang J, Liu H, Xing C, Chen J, Frey G, Boyle WJ, Short JM. Chang HW, et al. Antib Ther. 2025 Apr 10;8(2):145-156. doi: 10.1093/abt/tbaf006. eCollection 2025 Apr. Antib Ther. 2025. PMID: 40491605 Free PMC article.
In vivo, mecbotamab vedotin exhibited potent and lasting antitumor effects in human cancer xenograft mouse models. Furthermore, in nonhuman primates, mecbotamab vedotin demonstrated excellent tolerability at doses of up to 5 mg/kg and maintained linker-payload stabi …
In vivo, mecbotamab vedotin exhibited potent and lasting antitumor effects in human cancer xenograft mouse models. Furthermore, in no …