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Thiazolidinediones inhibit TNFalpha induction of PAI-1 independent of PPARgamma activation.
Liu HB, Hu YS, Medcalf RL, Simpson RW, Dear AE. Liu HB, et al. Among authors: medcalf rl. Biochem Biophys Res Commun. 2005 Aug 19;334(1):30-7. doi: 10.1016/j.bbrc.2005.06.055. Biochem Biophys Res Commun. 2005. PMID: 15990085
Plasminogen activator inhibitor type 2 gene induction by tumor necrosis factor and phorbol ester involves transcriptional and post-transcriptional events. Identification of a functional nonameric AU-rich motif in the 3'-untranslated region.
Maurer F, Medcalf RL. Maurer F, et al. Among authors: medcalf rl. J Biol Chem. 1996 Oct 18;271(42):26074-80. doi: 10.1074/jbc.271.42.26074. J Biol Chem. 1996. PMID: 8824249
Molecular mechanisms governing tumor-necrosis-factor-mediated regulation of plasminogen-activator inhibitor type-2 gene expression.
Dear AE, Shen Y, Rüegg M, Medcalf RL. Dear AE, et al. Among authors: medcalf rl. Eur J Biochem. 1996 Oct 1;241(1):93-100. doi: 10.1111/j.1432-1033.1996.0093t.x. Eur J Biochem. 1996. PMID: 8898893
Urokinase-mediated transactivation of the plasminogen activator inhibitor type 2 (PAI-2) gene promoter in HT-1080 cells utilises AP-1 binding sites and potentiates phorbol ester-mediated induction of endogenous PAI-2 mRNA.
Dear AE, Costa M, Medcalf RL. Dear AE, et al. Among authors: medcalf rl. FEBS Lett. 1997 Feb 3;402(2-3):265-72. doi: 10.1016/s0014-5793(97)00002-1. FEBS Lett. 1997. PMID: 9037208
Transcriptional regulation of the tissue-type plasminogen-activator gene in human endothelial cells: identification of nuclear factors that recognise functional elements in the tissue-type plasminogen-activator gene promoter.
Costa M, Shen Y, Maurer F, Medcalf RL. Costa M, et al. Among authors: medcalf rl. Eur J Biochem. 1998 Nov 15;258(1):123-31. doi: 10.1046/j.1432-1327.1998.2580123.x. Eur J Biochem. 1998. PMID: 9851700
An AU-rich sequence in the 3'-UTR of plasminogen activator inhibitor type 2 (PAI-2) mRNA promotes PAI-2 mRNA decay and provides a binding site for nuclear HuR.
Maurer F, Tierney M, Medcalf RL. Maurer F, et al. Among authors: medcalf rl. Nucleic Acids Res. 1999 Apr 1;27(7):1664-73. doi: 10.1093/nar/27.7.1664. Nucleic Acids Res. 1999. PMID: 10075998 Free PMC article.
Methylation-dependent silencing of the testis-specific Pdha-2 basal promoter occurs through selective targeting of an activating transcription factor/cAMP-responsive element-binding site.
Iannello RC, Gould JA, Young JC, Giudice A, Medcalf R, Kola I. Iannello RC, et al. Among authors: medcalf r. J Biol Chem. 2000 Jun 30;275(26):19603-8. doi: 10.1074/jbc.M001867200. J Biol Chem. 2000. PMID: 10766751
The novel anti-tumour agent oxamflatin differentially regulates urokinase and plasminogen activator inhibitor type 2 expression and inhibits urokinase-mediated proteolytic activity.
Dear AE, Medcalf RL. Dear AE, et al. Among authors: medcalf rl. Biochim Biophys Acta. 2000 Jun 21;1492(1):15-22. doi: 10.1016/s0167-4781(00)00041-5. Biochim Biophys Acta. 2000. PMID: 11004477
Overexpression of a dominant negative CREB protein in HT-1080 cells selectively disrupts plasminogen activator inhibitor type 2 but not tissue-type plasminogen activator gene expression.
Costa M, Shen Y, Medcalf RL. Costa M, et al. Among authors: medcalf rl. FEBS Lett. 2000 Sep 29;482(1-2):75-80. doi: 10.1016/s0014-5793(00)02030-5. FEBS Lett. 2000. PMID: 11018526
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