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IL-4-mediated drug resistance in colon cancer stem cells.
Todaro M, Perez Alea M, Scopelliti A, Medema JP, Stassi G. Todaro M, et al. Cell Cycle. 2008 Feb 1;7(3):309-13. doi: 10.4161/cc.7.3.5389. Epub 2007 Nov 30. Cell Cycle. 2008. PMID: 18235245 Review.
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.
Todaro M, Alea MP, Di Stefano AB, Cammareri P, Vermeulen L, Iovino F, Tripodo C, Russo A, Gulotta G, Medema JP, Stassi G. Todaro M, et al. Cell Stem Cell. 2007 Oct 11;1(4):389-402. doi: 10.1016/j.stem.2007.08.001. Cell Stem Cell. 2007. PMID: 18371377
Apoptosis and non-apoptotic deaths in cancer development and treatment response.
de Bruin EC, Medema JP. de Bruin EC, et al. Cancer Treat Rev. 2008 Dec;34(8):737-49. doi: 10.1016/j.ctrv.2008.07.001. Epub 2008 Aug 22. Cancer Treat Rev. 2008. PMID: 18722718 Review.
One renegade cancer stem cell?
Borovski T, Vermeulen L, Sprick MR, Medema JP. Borovski T, et al. Cell Cycle. 2009 Mar 15;8(6):803-8. doi: 10.4161/cc.8.6.7935. Epub 2009 Mar 26. Cell Cycle. 2009. PMID: 19221496
[Cancer stem cells].
Vermeulen L, Verhoeff JJ, Richel DJ, Medema JP. Vermeulen L, et al. Ned Tijdschr Geneeskd. 2009 Feb 14;153(7):286-90. Ned Tijdschr Geneeskd. 2009. PMID: 19291944 Review. Dutch. No abstract available.
The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation.
Kemper K, Sprick MR, de Bree M, Scopelliti A, Vermeulen L, Hoek M, Zeilstra J, Pals ST, Mehmet H, Stassi G, Medema JP. Kemper K, et al. Cancer Res. 2010 Jan 15;70(2):719-29. doi: 10.1158/0008-5472.CAN-09-1820. Epub 2010 Jan 12. Cancer Res. 2010. PMID: 20068153
Exploring cancer stem cell niche directed tumor growth.
Sottoriva A, Sloot PM, Medema JP, Vermeulen L. Sottoriva A, et al. Cell Cycle. 2010 Apr 15;9(8):1472-9. doi: 10.4161/cc.9.8.11198. Epub 2010 Apr 15. Cell Cycle. 2010. PMID: 20372084
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.
Vermeulen L, De Sousa E Melo F, van der Heijden M, Cameron K, de Jong JH, Borovski T, Tuynman JB, Todaro M, Merz C, Rodermond H, Sprick MR, Kemper K, Richel DJ, Stassi G, Medema JP. Vermeulen L, et al. Nat Cell Biol. 2010 May;12(5):468-76. doi: 10.1038/ncb2048. Epub 2010 Apr 25. Nat Cell Biol. 2010. PMID: 20418870
Colon cancer stem cells: promise of targeted therapy.
Todaro M, Francipane MG, Medema JP, Stassi G. Todaro M, et al. Gastroenterology. 2010 Jun;138(6):2151-62. doi: 10.1053/j.gastro.2009.12.063. Gastroenterology. 2010. PMID: 20420952 Review.
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