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Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.
Tanenbaum ME, Macůrek L, Galjart N, Medema RH. Tanenbaum ME, et al. Among authors: medema rh. EMBO J. 2008 Dec 17;27(24):3235-45. doi: 10.1038/emboj.2008.242. Epub 2008 Nov 20. EMBO J. 2008. PMID: 19020519 Free PMC article.
Insulin stimulation of gene expression mediated by p21ras activation.
Burgering BM, Medema RH, Maassen JA, van de Wetering ML, van der Eb AJ, McCormick F, Bos JL. Burgering BM, et al. Among authors: medema rh. EMBO J. 1991 May;10(5):1103-9. EMBO J. 1991. PMID: 2022184 Free PMC article.
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension.
Lens SM, Wolthuis RM, Klompmaker R, Kauw J, Agami R, Brummelkamp T, Kops G, Medema RH. Lens SM, et al. Among authors: medema rh. EMBO J. 2003 Jun 16;22(12):2934-47. doi: 10.1093/emboj/cdg307. EMBO J. 2003. PMID: 12805209 Free PMC article.
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.
Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC. Baas AF, et al. Among authors: medema r. EMBO J. 2003 Jun 16;22(12):3062-72. doi: 10.1093/emboj/cdg292. EMBO J. 2003. PMID: 12805220 Free PMC article.
Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis.
van Vugt MA, van de Weerdt BC, Vader G, Janssen H, Calafat J, Klompmaker R, Wolthuis RM, Medema RH. van Vugt MA, et al. Among authors: medema rh. J Biol Chem. 2004 Aug 27;279(35):36841-54. doi: 10.1074/jbc.M313681200. Epub 2004 Jun 21. J Biol Chem. 2004. PMID: 15210710
Ablation of the spindle assembly checkpoint by a compound targeting Mps1.
Schmidt M, Budirahardja Y, Klompmaker R, Medema RH. Schmidt M, et al. Among authors: medema rh. EMBO Rep. 2005 Sep;6(9):866-72. doi: 10.1038/sj.embor.7400483. EMBO Rep. 2005. PMID: 16113653 Free PMC article.
The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis.
Akhmanova A, Mausset-Bonnefont AL, van Cappellen W, Keijzer N, Hoogenraad CC, Stepanova T, Drabek K, van der Wees J, Mommaas M, Onderwater J, van der Meulen H, Tanenbaum ME, Medema RH, Hoogerbrugge J, Vreeburg J, Uringa EJ, Grootegoed JA, Grosveld F, Galjart N. Akhmanova A, et al. Among authors: medema rh. Genes Dev. 2005 Oct 15;19(20):2501-15. doi: 10.1101/gad.344505. Genes Dev. 2005. PMID: 16230537 Free PMC article.
Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.
Vader G, Kauw JJ, Medema RH, Lens SM. Vader G, et al. Among authors: medema rh. EMBO Rep. 2006 Jan;7(1):85-92. doi: 10.1038/sj.embor.7400562. EMBO Rep. 2006. PMID: 16239925 Free PMC article.
CLIP-170 facilitates the formation of kinetochore-microtubule attachments.
Tanenbaum ME, Galjart N, van Vugt MA, Medema RH. Tanenbaum ME, et al. Among authors: medema rh. EMBO J. 2006 Jan 11;25(1):45-57. doi: 10.1038/sj.emboj.7600916. Epub 2005 Dec 15. EMBO J. 2006. PMID: 16362039 Free PMC article.
Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres.
Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH. Lens SM, et al. Among authors: medema rh. Mol Biol Cell. 2006 Apr;17(4):1897-909. doi: 10.1091/mbc.e05-08-0727. Epub 2006 Jan 25. Mol Biol Cell. 2006. PMID: 16436504 Free PMC article.
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