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Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts.
Bhattacharjee S, Hamberger F, Ravichandra A, Miller M, Nair A, Affo S, Filliol A, Chin L, Savage TM, Yin D, Wirsik NM, Mehal A, Arpaia N, Seki E, Mack M, Zhu D, Sims PA, Kalluri R, Stanger BZ, Olive KP, Schmidt T, Wells RG, Mederacke I, Schwabe RF. Bhattacharjee S, et al. Among authors: mederacke i. J Clin Invest. 2021 Jun 1;131(11):e146987. doi: 10.1172/JCI146987. J Clin Invest. 2021. PMID: 33905375 Free PMC article.
Deactivation of hepatic stellate cells during liver fibrosis resolution in mice.
Troeger JS, Mederacke I, Gwak GY, Dapito DH, Mu X, Hsu CC, Pradere JP, Friedman RA, Schwabe RF. Troeger JS, et al. Among authors: mederacke i. Gastroenterology. 2012 Oct;143(4):1073-83.e22. doi: 10.1053/j.gastro.2012.06.036. Epub 2012 Jun 27. Gastroenterology. 2012. PMID: 22750464 Free PMC article.
Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4.
Dapito DH, Mencin A, Gwak GY, Pradere JP, Jang MK, Mederacke I, Caviglia JM, Khiabanian H, Adeyemi A, Bataller R, Lefkowitch JH, Bower M, Friedman R, Sartor RB, Rabadan R, Schwabe RF. Dapito DH, et al. Among authors: mederacke i. Cancer Cell. 2012 Apr 17;21(4):504-16. doi: 10.1016/j.ccr.2012.02.007. Cancer Cell. 2012. PMID: 22516259 Free PMC article.
The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver.
Mederacke I, Filliol A, Affo S, Nair A, Hernandez C, Sun Q, Hamberger F, Brundu F, Chen Y, Ravichandra A, Huebener P, Anke H, Shi H, Martínez García de la Torre RA, Smith JR, Henderson NC, Vondran FWR, Rothlin CV, Baehre H, Tabas I, Sancho-Bru P, Schwabe RF. Mederacke I, et al. Sci Transl Med. 2022 Apr 6;14(639):eabe5795. doi: 10.1126/scitranslmed.abe5795. Epub 2022 Apr 6. Sci Transl Med. 2022. PMID: 35385339 Free PMC article.
59 results