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Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2.
Afkhami S, D'Agostino MR, Zhang A, Stacey HD, Marzok A, Kang A, Singh R, Bavananthasivam J, Ye G, Luo X, Wang F, Ang JC, Zganiacz A, Sankar U, Kazhdan N, Koenig JFE, Phelps A, Gameiro SF, Tang S, Jordana M, Wan Y, Mossman KL, Jeyanathan M, Gillgrass A, Medina MFC, Smaill F, Lichty BD, Miller MS, Xing Z. Afkhami S, et al. Among authors: medina mfc. Cell. 2022 Mar 3;185(5):896-915.e19. doi: 10.1016/j.cell.2022.02.005. Epub 2022 Feb 9. Cell. 2022. PMID: 35180381 Free PMC article.
Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans.
Jeyanathan M, Fritz DK, Afkhami S, Aguirre E, Howie KJ, Zganiacz A, Dvorkin-Gheva A, Thompson MR, Silver RF, Cusack RP, Lichty BD, O'Byrne PM, Kolb M, Medina MFC, Dolovich MB, Satia I, Gauvreau GM, Xing Z, Smaill F. Jeyanathan M, et al. Among authors: medina mfc. JCI Insight. 2022 Feb 8;7(3):e155655. doi: 10.1172/jci.insight.155655. JCI Insight. 2022. PMID: 34990408 Free PMC article.