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Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.
Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A. Barbarroja N, et al. Diabetes. 2015 Apr;64(4):1180-92. doi: 10.2337/db14-0359. Epub 2014 Oct 28. Diabetes. 2015. PMID: 25352638
Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network.
Lagathu C, Christodoulides C, Virtue S, Cawthorn WP, Franzin C, Kimber WA, Nora ED, Campbell M, Medina-Gomez G, Cheyette BN, Vidal-Puig AJ, Sethi JK. Lagathu C, et al. Diabetes. 2009 Mar;58(3):609-19. doi: 10.2337/db08-1180. Epub 2008 Dec 10. Diabetes. 2009. PMID: 19073771 Free PMC article.
DLK1/PREF1 regulates nutrient metabolism and protects from steatosis.
Charalambous M, Da Rocha ST, Radford EJ, Medina-Gomez G, Curran S, Pinnock SB, Ferrón SR, Vidal-Puig A, Ferguson-Smith AC. Charalambous M, et al. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16088-93. doi: 10.1073/pnas.1406119111. Epub 2014 Oct 27. Proc Natl Acad Sci U S A. 2014. PMID: 25349437 Free PMC article.
Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo.
Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešič M, Urade Y, Griffin JL, Vidal-Puig A. Virtue S, et al. PLoS One. 2012;7(7):e39512. doi: 10.1371/journal.pone.0039512. Epub 2012 Jul 5. PLoS One. 2012. PMID: 22792179 Free PMC article.
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.
Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. Medina-Gomez G, et al. PLoS Genet. 2007 Apr 27;3(4):e64. doi: 10.1371/journal.pgen.0030064. PLoS Genet. 2007. PMID: 17465682 Free PMC article.
The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.
Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. Medina-Gomez G, et al. Diabetes. 2005 Jun;54(6):1706-16. doi: 10.2337/diabetes.54.6.1706. Diabetes. 2005. PMID: 15919792 Free PMC article.
The peroxisome proliferator-activated receptor-gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitro.
Jitrapakdee S, Slawik M, Medina-Gomez G, Campbell M, Wallace JC, Sethi JK, O'rahilly S, Vidal-Puig AJ. Jitrapakdee S, et al. J Biol Chem. 2005 Jul 22;280(29):27466-76. doi: 10.1074/jbc.M503836200. Epub 2005 May 25. J Biol Chem. 2005. PMID: 15917242 Free PMC article.
Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia.
Gurung IS, Medina-Gomez G, Kis A, Baker M, Velagapudi V, Neogi SG, Campbell M, Rodriguez-Cuenca S, Lelliott C, McFarlane I, Oresic M, Grace AA, Vidal-Puig A, Huang CL. Gurung IS, et al. Cardiovasc Res. 2011 Oct 1;92(1):29-38. doi: 10.1093/cvr/cvr155. Epub 2011 Jun 1. Cardiovasc Res. 2011. PMID: 21632884 Free PMC article.
Metabolomic and Lipidomic Analysis of the Heart of Peroxisome Proliferator-Activated Receptor-γ Coactivator 1-β Knock Out Mice on a High Fat Diet.
McCombie G, Medina-Gomez G, Lelliott CJ, Vidal-Puig A, Griffin JL. McCombie G, et al. Metabolites. 2012 Jun 18;2(2):366-81. doi: 10.3390/metabo2020366. Metabolites. 2012. PMID: 24957515 Free PMC article.
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