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Identification and quantification of aberrant crypt foci and microadenomas in the human colon.
Roncucci L, Stamp D, Medline A, Cullen JB, Bruce WR. Roncucci L, et al. Hum Pathol. 1991 Mar;22(3):287-94. doi: 10.1016/0046-8177(91)90163-j. Hum Pathol. 1991. PMID: 1706308
Twenty-seven colon resections from patients affected by familial adenomatous polyposis (FAP, five cases), colorectal cancer (CRC, 12 cases), and benign diseases of the large bowel (BD, 10 cases) were collected from a pathology repository or immediately after operation. ... …
Twenty-seven colon resections from patients affected by familial adenomatous polyposis (FAP, five cases), colorectal cancer (CRC, 12 cases), …
Effects of dietary folate on ulcerative colitis-associated colorectal carcinogenesis in the interleukin 2- and beta(2)-microglobulin-deficient mice.
Carrier J, Medline A, Sohn KJ, Choi M, Martin R, Hwang SW, Kim YI. Carrier J, et al. Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1262-7. Cancer Epidemiol Biomarkers Prev. 2003. PMID: 14652292
However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate deficiency on UC-associated colorectal carcinogenesis in this model....
However, the high mortality observed in the folate-deficient group precludes a definitive conclusion concerning the effect of folate …
Marginal dietary thiamin deficiency induces the formation of colonic aberrant crypt foci (ACF) in rats.
Bruce WR, Furrer R, Shangari N, O'Brien PJ, Medline A, Wang Y. Bruce WR, et al. Cancer Lett. 2003 Dec 30;202(2):125-9. doi: 10.1016/j.canlet.2003.08.005. Cancer Lett. 2003. PMID: 14643441
To evaluate whether marginal deficiency poses a carcinogenesis risk we fed rats AIN-76A sucrose-based diets containing thiamin at 4.9 (control), 1.6 or 1.0 mg/kg diet and examined their colons after 160 days. ...
To evaluate whether marginal deficiency poses a carcinogenesis risk we fed rats AIN-76A sucrose-based diets containing thiamin at 4.9 …
Risk factors for colorectal cancer in man induce aberrant crypt foci in rats: Preliminary findings.
Yang K, Fard S, Furrer R, Archer MC, Bruce WR, Lip H, Mehta R, O'Brien PJ, Giacca A, Ward WE, Femia AP, Caderni G, Medline A, Banks K. Yang K, et al. Among authors: medline a. Nutr Cancer. 2016;68(1):94-104. doi: 10.1080/01635581.2016.1115098. Epub 2015 Dec 28. Nutr Cancer. 2016. PMID: 26709971 Free PMC article.
Effect of folic acid supplementation on the progression of colorectal aberrant crypt foci.
Lindzon GM, Medline A, Sohn KJ, Depeint F, Croxford R, Kim YI. Lindzon GM, et al. Carcinogenesis. 2009 Sep;30(9):1536-43. doi: 10.1093/carcin/bgp152. Epub 2009 Jun 18. Carcinogenesis. 2009. PMID: 19541855
Male Sprague-Dawley rats (n = 152) were placed on a control diet (2 mg folic acid/kg diet) at weaning and ACF were induced by azoxymethane. ...At 34 weeks of age, rats were killed, and colorectal tumor parameters, plasma folate and homocysteine (a sensitive inverse …
Male Sprague-Dawley rats (n = 152) were placed on a control diet (2 mg folic acid/kg diet) at weaning and ACF were induced by azoxyme …
Possible mechanisms relating diet and risk of colon cancer.
Bruce WR, Giacca A, Medline A. Bruce WR, et al. Cancer Epidemiol Biomarkers Prev. 2000 Dec;9(12):1271-9. Cancer Epidemiol Biomarkers Prev. 2000. PMID: 11142411 Review.
These circulating factors subject colonic epithelial cells to a proliferative stimulus and also expose them to reactive oxygen intermediates. ...These observations suggest the following mechanism: focal loss of epithelial barrier function resulting from a failure of …
These circulating factors subject colonic epithelial cells to a proliferative stimulus and also expose them to reactive oxygen interm …
Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse.
Song J, Medline A, Mason JB, Gallinger S, Kim YI. Song J, et al. Cancer Res. 2000 Oct 1;60(19):5434-40. Cancer Res. 2000. PMID: 11034085
However, increasing dietary folate levels significantly reduced the number of ileal, but not duodenal or jejunal, polyps in a dose-dependent manner (P-trend = 0.001); folate supplementation at 20 mg/kg diet was associated with a 68-78% reduction in the number of ile …
However, increasing dietary folate levels significantly reduced the number of ileal, but not duodenal or jejunal, polyps in a dose-de …
Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice.
Song J, Sohn KJ, Medline A, Ash C, Gallinger S, Kim YI. Song J, et al. Cancer Res. 2000 Jun 15;60(12):3191-9. Cancer Res. 2000. PMID: 10866310
A recently developed murine model of intestinal tumorigenesis, which carries a heterozygous mutation in the Apc gene and a null mutation in the Msh2 gene (Apc+/-Msh2-/-), was used to determine the effect of dietary folate on intestinal tumorigenesis. ...Serum
A recently developed murine model of intestinal tumorigenesis, which carries a heterozygous mutation in the Apc gene and a
Thermally oxidized dietary fat and colon carcinogenesis in rodents.
Yang CM, Kendall CW, Stamp D, Medline A, Archer MC, Bruce WR. Yang CM, et al. Nutr Cancer. 1998;30(1):69-73. doi: 10.1080/01635589809514643. Nutr Cancer. 1998. PMID: 9507516
ACF size was not affected by less extensively oxidized beef tallow or by a 10-fold reduction of dietary alpha-tocopherol during the growth of the ACF. ...
ACF size was not affected by less extensively oxidized beef tallow or by a 10-fold reduction of dietary alpha-tocopherol during the g …
Promotion of colonic microadenoma growth in mice and rats fed cooked sugar or cooked casein and fat.
Corpet DE, Stamp D, Medline A, Minkin S, Archer MC, Bruce WR. Corpet DE, et al. Cancer Res. 1990 Nov 1;50(21):6955-8. Cancer Res. 1990. PMID: 2208161
CF1 mice and Fisher 344 rats were initiated with azoxymethane, with 152 mice receiving four weekly i.p. injections of 5 mg/kg, 59 rats receiving a single injection of 20 mg/kg, and 24 rats receiving 30 mg/kg. A week after the last injection, the animals were randoml …
CF1 mice and Fisher 344 rats were initiated with azoxymethane, with 152 mice receiving four weekly i.p. injections of 5 mg/kg, 59 rats recei …
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