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Involvement of TLR2 and TLR4 in cell responses to Rickettsia akari.
Quevedo-Diaz MA, Song C, Xiong Y, Chen H, Wahl LM, Radulovic S, Medvedev AE. Quevedo-Diaz MA, et al. Among authors: medvedev ae. J Leukoc Biol. 2010 Oct;88(4):675-85. doi: 10.1189/jlb.1009674. Epub 2010 Jul 8. J Leukoc Biol. 2010. PMID: 20616112 Free PMC article.
Transfection-based complementation of TLR2/4-negative HEK293T cells with human TLR2 or TLR4 coexpressed with CD14 and MD-2 enabled IκB-α degradation, NF-κB reporter activation, and IL-8 expression in response to heat-killed (HK) R. akari. ...Live and HK R. akari exe …
Transfection-based complementation of TLR2/4-negative HEK293T cells with human TLR2 or TLR4 coexpressed with CD14 and MD-2 ena …
The R753Q polymorphism in Toll-like receptor 2 (TLR2) attenuates innate immune responses to mycobacteria and impairs MyD88 adapter recruitment to TLR2.
Pattabiraman G, Panchal R, Medvedev AE. Pattabiraman G, et al. Among authors: medvedev ae. J Biol Chem. 2017 Jun 23;292(25):10685-10695. doi: 10.1074/jbc.M117.784470. Epub 2017 Apr 25. J Biol Chem. 2017. PMID: 28442574 Free PMC article.
Toll-like receptor 2 (TLR2) plays a critical role in host defenses against mycobacterial infections. The R753Q TLR2 polymorphism has been associated with increased incidence of tuberculosis and infections with non-tuberculous mycobacteria in human populations, but t …
Toll-like receptor 2 (TLR2) plays a critical role in host defenses against mycobacterial infections. The R753Q TLR2 polymorphi …
Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonists.
Chen H, Cowan MJ, Hasday JD, Vogel SN, Medvedev AE. Chen H, et al. Among authors: medvedev ae. J Immunol. 2007 Nov 1;179(9):6097-106. doi: 10.4049/jimmunol.179.9.6097. J Immunol. 2007. PMID: 17947684 Free article.
In this study, we examined whether smokers' alveolar macrophages (AM) exhibit impaired sensing of bacterial components via TLR2 and TLR4 and determined the effect of smoking on expression levels of TLR2, TLR4 and coreceptors, and activation of signaling intermediate …
In this study, we examined whether smokers' alveolar macrophages (AM) exhibit impaired sensing of bacterial components via TLR2 and T …
Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.
Murphy MB, Xiong Y, Pattabiraman G, Manavalan TT, Qiu F, Medvedev AE. Murphy MB, et al. Among authors: medvedev ae. J Leukoc Biol. 2015 Dec;98(6):963-74. doi: 10.1189/jlb.2VMA0515-229RR. Epub 2015 Aug 26. J Leukoc Biol. 2015. PMID: 26310831 Free PMC article.
Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter.
Shoenfelt J, Mitkus RJ, Zeisler R, Spatz RO, Powell J, Fenton MJ, Squibb KA, Medvedev AE. Shoenfelt J, et al. Among authors: medvedev ae. J Leukoc Biol. 2009 Aug;86(2):303-12. doi: 10.1189/jlb.1008587. J Leukoc Biol. 2009. PMID: 19406832 Free PMC article.
Overexpression of TLR2 in TLR2/4-deficient human embryonic kidney 293 cells imparted PM2.5 sensitivity, as judged by IL-8 gene expression, whereas NIST SRM 1648, but not PM2.5 elicited IL-8 expression in 293/TLR4/MD-2 transfectants. ...These data indicate differenti …
Overexpression of TLR2 in TLR2/4-deficient human embryonic kidney 293 cells imparted PM2.5 sensitivity, as judged by IL-8 gene …
Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.
Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE. Murphy M, et al. Among authors: medvedev ae. J Biol Chem. 2015 Jul 31;290(31):19218-32. doi: 10.1074/jbc.M115.640128. Epub 2015 Jun 16. J Biol Chem. 2015. PMID: 26082489 Free PMC article.
Overexpression of Pellino-1 in 293/TLR2 and 293/TLR4/MD2 cells enhanced TLR2- and TLR4-induced nuclear factor κB (NF-κB) and expression of IL-8 mRNA, whereas Pellino-1 knockdown reduced these responses. Pellino-1 ablation in THP-1 cells impaired induction of myeloid …
Overexpression of Pellino-1 in 293/TLR2 and 293/TLR4/MD2 cells enhanced TLR2- and TLR4-induced nuclear factor κB (NF-κB) and e …
IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance.
Xiong Y, Pennini M, Vogel SN, Medvedev AE. Xiong Y, et al. Among authors: medvedev ae. J Leukoc Biol. 2013 Aug;94(2):291-300. doi: 10.1189/jlb.0812401. Epub 2013 May 21. J Leukoc Biol. 2013. PMID: 23695305 Free PMC article.
Pretreatment of WT macrophages with Pam3Cys, a TLR2-TLR1 agonist, ablated p-p38 and p-JNK in response to challenge with Pam3Cys and LPS, whereas IRAK4(KDKI) macrophages exhibited attenuated TLR2-elicited homo- and heterotolerance at the level of MAPK activation. Thu …
Pretreatment of WT macrophages with Pam3Cys, a TLR2-TLR1 agonist, ablated p-p38 and p-JNK in response to challenge with Pam3Cys and L …
R753Q polymorphism inhibits Toll-like receptor (TLR) 2 tyrosine phosphorylation, dimerization with TLR6, and recruitment of myeloid differentiation primary response protein 88.
Xiong Y, Song C, Snyder GA, Sundberg EJ, Medvedev AE. Xiong Y, et al. Among authors: medvedev ae. J Biol Chem. 2012 Nov 2;287(45):38327-37. doi: 10.1074/jbc.M112.375493. Epub 2012 Sep 19. J Biol Chem. 2012. PMID: 22992740 Free PMC article.
The R753Q polymorphism in the Toll-IL-1 receptor domain of Toll-like receptor 2 (TLR2) has been linked to increased incidence of tuberculosis and other infectious diseases, but the mechanisms by which it affects TLR2 functions are unclear. ...Notably, even a 100-fol …
The R753Q polymorphism in the Toll-IL-1 receptor domain of Toll-like receptor 2 (TLR2) has been linked to increased incidence of tube …
Pathogenic Old World arenaviruses inhibit TLR2/Mal-dependent proinflammatory cytokines in vitro.
Hayes MW, Carrion R Jr, Nunneley J, Medvedev AE, Salvato MS, Lukashevich IS. Hayes MW, et al. Among authors: medvedev ae. J Virol. 2012 Jul;86(13):7216-26. doi: 10.1128/JVI.06508-11. Epub 2012 Apr 24. J Virol. 2012. PMID: 22532679 Free PMC article.
Here we have shown that cells infected with LASV or with LCMV-WE suppressed Toll-like receptor 2 (TLR2)-dependent proinflammatory cytokine responses. ...In contrast, nonpathogenic Mopeia virus, which is a genetic relative of LASV and LCMV-Arm induced robust responses that …
Here we have shown that cells infected with LASV or with LCMV-WE suppressed Toll-like receptor 2 (TLR2)-dependent proinflammatory cyt …
Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.
Medvedev AE, Henneke P, Schromm A, Lien E, Ingalls R, Fenton MJ, Golenbock DT, Vogel SN. Medvedev AE, et al. J Immunol. 2001 Aug 15;167(4):2257-67. doi: 10.4049/jimmunol.167.4.2257. J Immunol. 2001. PMID: 11490013 Free article.
Transfected TLRs exhibited proper signaling functions, as evidenced by increased LPS responsiveness of 3E10/TLR4 cells and acquisition of sensitivity to TLR2-specific ligands upon transfection of TLR2 into TLR2-negative 3E10 cells. Pretreatment of cells with …
Transfected TLRs exhibited proper signaling functions, as evidenced by increased LPS responsiveness of 3E10/TLR4 cells and acquisition of se …
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