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14 results

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Page 1
Involvement of TLR2 and TLR4 in cell responses to Rickettsia akari.
Quevedo-Diaz MA, Song C, Xiong Y, Chen H, Wahl LM, Radulovic S, Medvedev AE. Quevedo-Diaz MA, et al. Among authors: medvedev ae. J Leukoc Biol. 2010 Oct;88(4):675-85. doi: 10.1189/jlb.1009674. Epub 2010 Jul 8. J Leukoc Biol. 2010. PMID: 20616112 Free PMC article.
Transfection-based complementation of TLR2/4-negative HEK293T cells with human TLR2 or TLR4 coexpressed with CD14 and MD-2 enabled IkappaB-alpha degradation, NF-kappaB reporter activation, and IL-8 expression in response to heat-killed (HK) R. akari. ...Live and HK …
Transfection-based complementation of TLR2/4-negative HEK293T cells with human TLR2 or TLR4 coexpressed with CD14 and MD-2 ena …
Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter.
Shoenfelt J, Mitkus RJ, Zeisler R, Spatz RO, Powell J, Fenton MJ, Squibb KA, Medvedev AE. Shoenfelt J, et al. Among authors: medvedev ae. J Leukoc Biol. 2009 Aug;86(2):303-12. doi: 10.1189/jlb.1008587. J Leukoc Biol. 2009. PMID: 19406832 Free PMC article.
Consistent with the shared use of MyD88 by TLR2 and TLR4, cytokine responses of MyD88(-/-) macrophages to both types of air PM were significantly reduced. These data indicate differential utilization of TLR2 and TLR4 but shared use of MyD88 by fine and coarse air po …
Consistent with the shared use of MyD88 by TLR2 and TLR4, cytokine responses of MyD88(-/-) macrophages to both types of air PM were s …
The R753Q polymorphism in Toll-like receptor 2 (TLR2) attenuates innate immune responses to mycobacteria and impairs MyD88 adapter recruitment to TLR2.
Pattabiraman G, Panchal R, Medvedev AE. Pattabiraman G, et al. Among authors: medvedev ae. J Biol Chem. 2017 Jun 23;292(25):10685-10695. doi: 10.1074/jbc.M117.784470. Epub 2017 Apr 25. J Biol Chem. 2017. PMID: 28442574 Free PMC article.
Toll-like receptor 2 (TLR2) plays a critical role in host defenses against mycobacterial infections. The R753Q TLR2 polymorphism has been associated with increased incidence of tuberculosis and infections with non-tuberculous mycobacteria in human populations, but t …
Toll-like receptor 2 (TLR2) plays a critical role in host defenses against mycobacterial infections. The R753Q TLR2 polymorphi …
Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonists.
Chen H, Cowan MJ, Hasday JD, Vogel SN, Medvedev AE. Chen H, et al. Among authors: medvedev ae. J Immunol. 2007 Nov 1;179(9):6097-106. doi: 10.4049/jimmunol.179.9.6097. J Immunol. 2007. PMID: 17947684
In this study, we examined whether smokers' alveolar macrophages (AM) exhibit impaired sensing of bacterial components via TLR2 and TLR4 and determined the effect of smoking on expression levels of TLR2, TLR4 and coreceptors, and activation of signaling intermediate …
In this study, we examined whether smokers' alveolar macrophages (AM) exhibit impaired sensing of bacterial components via TLR2 and T …
IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance.
Xiong Y, Pennini M, Vogel SN, Medvedev AE. Xiong Y, et al. Among authors: medvedev ae. J Leukoc Biol. 2013 Aug;94(2):291-300. doi: 10.1189/jlb.0812401. Epub 2013 May 21. J Leukoc Biol. 2013. PMID: 23695305 Free PMC article.
In this study, we addressed mechanistically the role of IRAK4 kinase activity in TLR4- and TLR2-induced tolerance using macrophages from WT versus IRAK4(KDKI) mice. ...Thus, IRAK4 kinase activity is not required for the induction of endotoxin tolerance but contributes sign …
In this study, we addressed mechanistically the role of IRAK4 kinase activity in TLR4- and TLR2-induced tolerance using macrophages f …
Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.
Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE. Murphy M, et al. Among authors: medvedev ae. J Biol Chem. 2015 Jul 31;290(31):19218-32. doi: 10.1074/jbc.M115.640128. Epub 2015 Jun 16. J Biol Chem. 2015. PMID: 26082489 Free PMC article.
LPS stimulation increased Pellino-1 mRNA and protein expression in macrophages from mice injected with saline and in medium-pretreated human monocytes, THP-1, and MonoMac-6 cells, whereas endotoxin tolerization abrogated LPS inducibility of Pellino-1. Overexpression of Pellino-1 …
LPS stimulation increased Pellino-1 mRNA and protein expression in macrophages from mice injected with saline and in medium-pretreated human …
Pathogenic Old World arenaviruses inhibit TLR2/Mal-dependent proinflammatory cytokines in vitro.
Hayes MW, Carrion R Jr, Nunneley J, Medvedev AE, Salvato MS, Lukashevich IS. Hayes MW, et al. Among authors: medvedev ae. J Virol. 2012 Jul;86(13):7216-26. doi: 10.1128/JVI.06508-11. Epub 2012 Apr 24. J Virol. 2012. PMID: 22532679 Free PMC article.
Here we have shown that cells infected with LASV or with LCMV-WE suppressed Toll-like receptor 2 (TLR2)-dependent proinflammatory cytokine responses. The persisting isolate LCMV clone 13 (CL13) also failed to stimulate interleukin-6 (IL-6) in macrophages. In contrast, nonp …
Here we have shown that cells infected with LASV or with LCMV-WE suppressed Toll-like receptor 2 (TLR2)-dependent proinflammatory cyt …
Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance.
Medvedev AE, Piao W, Shoenfelt J, Rhee SH, Chen H, Basu S, Wahl LM, Fenton MJ, Vogel SN. Medvedev AE, et al. J Biol Chem. 2007 Jun 1;282(22):16042-53. doi: 10.1074/jbc.M606781200. Epub 2007 Mar 28. J Biol Chem. 2007. PMID: 17392283 Free PMC article.
Pretreatment of human embryonic kidney (HEK) 293/TLR4/MD-2 cells with protein tyrosine kinase or Src kinase inhibitors suppressed LPS-driven TLR4 tyrosine phosphorylation, p38 and NF-kappaB activation. TLR2 and TLR4 agonists induced TLR tyrosine phosphorylation in HEK293 c …
Pretreatment of human embryonic kidney (HEK) 293/TLR4/MD-2 cells with protein tyrosine kinase or Src kinase inhibitors suppressed LPS-driven …
Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.
Medvedev AE, Henneke P, Schromm A, Lien E, Ingalls R, Fenton MJ, Golenbock DT, Vogel SN. Medvedev AE, et al. J Immunol. 2001 Aug 15;167(4):2257-67. doi: 10.4049/jimmunol.167.4.2257. J Immunol. 2001. PMID: 11490013
To this end, Chinese hamster ovary/CD14 cells stably transfected with a NF-kappaB-dependent reporter construct, endothelial leukocyte adhesion molecule CD25 (the 3E10 clone), were engineered to overexpress either human TLR2 or TLR4. Transfected TLRs exhibited proper signal …
To this end, Chinese hamster ovary/CD14 cells stably transfected with a NF-kappaB-dependent reporter construct, endothelial leukocyte adhesi …
14 results