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Did you mean megakaryocyte differentiation and wnt (18 results)?
A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production.
Seo H, Chen SJ, Hashimoto K, Endo H, Nishi Y, Ohta A, Yamamoto T, Hotta A, Sawaguchi A, Hayashi H, Koseki N, Murphy GJ, Fukuda K, Sugimoto N, Eto K. Seo H, et al. Blood Adv. 2018 Sep 11;2(17):2262-2272. doi: 10.1182/bloodadvances.2018019547. Blood Adv. 2018. PMID: 30206099 Free PMC article.
During maturation, megakaryocytes (MKs) express beta1-tubulin (TUBB1) and rearrange their microtubule components to enlarge, form proplatelets, and eventually release platelets. ...We identified several compounds that significantly improved the efficiency of PLP production …
During maturation, megakaryocytes (MKs) express beta1-tubulin (TUBB1) and rearrange their microtubule components to enlarge, form pro …
GSK-3beta negatively regulates megakaryocyte differentiation and platelet production from primary human bone marrow cells in vitro.
Ono M, Matsubara Y, Shibano T, Ikeda Y, Murata M. Ono M, et al. Platelets. 2011;22(3):196-203. doi: 10.3109/09537104.2010.541959. Epub 2011 Jan 13. Platelets. 2011. PMID: 21231855
To identify the target(s) of GSK-3beta inhibition during differentiation into MK lineage cells, we performed a differential gene expression study and subsequent pathway analysis of the large (MK)-sized CD41 (+)/propidium iodide (-) cells cultured in TWS119 (+/-) for …
To identify the target(s) of GSK-3beta inhibition during differentiation into MK lineage cells, we performed a differential ge …
The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells.
Paluru P, Hudock KM, Cheng X, Mills JA, Ying L, Galvão AM, Lu L, Tiyaboonchai A, Sim X, Sullivan SK, French DL, Gadue P. Paluru P, et al. Stem Cell Res. 2014 Mar;12(2):441-51. doi: 10.1016/j.scr.2013.12.003. Epub 2013 Dec 16. Stem Cell Res. 2014. PMID: 24412757 Free PMC article.
Previously, we found that Wnt signaling is required for primitive or yolk sac-derived-erythropoiesis using the murine embryonic stem cell (ESC) system. ...Canonical Wnt signaling also inhibits the expansion and/or survival of primitive erythrocytes and meg
Previously, we found that Wnt signaling is required for primitive or yolk sac-derived-erythropoiesis using the murine embryonic stem …
Role of let-7b/Fzd4 axis in mitochondrial biogenesis through wnt signaling: In neonatal and adult megakaryocytes.
Undi RB, Gutti U, Gutti RK. Undi RB, et al. Int J Biochem Cell Biol. 2016 Oct;79:61-68. doi: 10.1016/j.biocel.2016.08.009. Epub 2016 Aug 7. Int J Biochem Cell Biol. 2016. PMID: 27510711
HYPOTHESIS: MicroRNAs (miRNAs) have been shown to crucially involve in the regulation of stem-cell differentiation in normal as well as malignant hematopoiesis, but their role in regulation of biological differences between adult and neonatal megakaryopoiesis is unk …
HYPOTHESIS: MicroRNAs (miRNAs) have been shown to crucially involve in the regulation of stem-cell differentiation in normal a …
Multifaceted Actions of GFI1 and GFI1B in Hematopoietic Stem Cell Self-Renewal and Lineage Commitment.
Beauchemin H, Möröy T. Beauchemin H, et al. Front Genet. 2020 Oct 26;11:591099. doi: 10.3389/fgene.2020.591099. eCollection 2020. Front Genet. 2020. PMID: 33193732 Free PMC article. Review.
By contrast, GFI1 expression is lost in megakaryocyte precursors (MKPs) and in megakaryocyte-erythrocyte progenitors (MEPs), which maintain a high level of GFI1B expression. Consequently, GFI1 drives myeloid and lymphoid differentiation and GFI1B drives the development of …
By contrast, GFI1 expression is lost in megakaryocyte precursors (MKPs) and in megakaryocyte-erythrocyte progenitors (MEPs), which maintain …
Canonical Wnt signaling in megakaryocytes regulates proplatelet formation.
Macaulay IC, Thon JN, Tijssen MR, Steele BM, MacDonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, Bennett C, Watkins NA, He X, Fitzgerald DJ, Italiano JE Jr, Maguire PB. Macaulay IC, et al. Blood. 2013 Jan 3;121(1):188-96. doi: 10.1182/blood-2012-03-416875. Epub 2012 Nov 16. Blood. 2013. PMID: 23160460 Free PMC article.
Wnt signaling is involved in numerous aspects of vertebrate development and homeostasis, including the formation and function of blood cells. Here, we show that canonical and noncanonical Wnt signaling pathways are present and functional in megakaryocytes (MK
Wnt signaling is involved in numerous aspects of vertebrate development and homeostasis, including the formation and function of bloo
Microtubule plus-end tracking Adenopolyposis Coli negatively regulates proplatelet formation.
Strassel C, Moog S, Mallo L, Eckly A, Freund M, Gachet C, Lanza F. Strassel C, et al. Sci Rep. 2018 Oct 25;8(1):15808. doi: 10.1038/s41598-018-34118-y. Sci Rep. 2018. PMID: 30361531 Free PMC article.
Platelets are produced upon profound reorganization of mature megakaryocytes (MK) leading to proplatelet elongation and release into the blood stream, a process termed thrombopoiesis. ...Similarly an increased ploidy and amplification of the proplatelet network were observ …
Platelets are produced upon profound reorganization of mature megakaryocytes (MK) leading to proplatelet elongation and release into …
Differential expression of Wnt13 isoforms during leukemic cell differentiation.
Bunaciu RP, Tang T, Mao CD. Bunaciu RP, et al. Oncol Rep. 2008 Jul;20(1):195-201. Oncol Rep. 2008. PMID: 18575737
Wnt proteins control cell fate and differentiation during development. ...We investigated the expression of the human wnt13 in relation to leukemic cell differentiation. Differentiated endothelial cells expressed the highest levels of Wnt
Wnt proteins control cell fate and differentiation during development. ...We investigated the expression of the human w
Normal hematopoiesis and lack of β-catenin activation in osteoblasts of patients and mice harboring Lrp5 gain-of-function mutations.
Galán-Díez M, Isa A, Ponzetti M, Nielsen MF, Kassem M, Kousteni S. Galán-Díez M, et al. Biochim Biophys Acta. 2016 Mar;1863(3):490-498. doi: 10.1016/j.bbamcr.2015.11.037. Epub 2015 Dec 8. Biochim Biophys Acta. 2016. PMID: 26681532 Free PMC article.
The LDL receptor-related protein 5 (LRP5), initially proposed to be a co-receptor for Wnt proteins, in fact favors bone formation by suppressing gut-serotonin synthesis. ...We conclude that Lrp5 GOF mutations do not activate beta-catenin signaling in osteoblasts. As a resu …
The LDL receptor-related protein 5 (LRP5), initially proposed to be a co-receptor for Wnt proteins, in fact favors bone formation by …
The role of beta-catenin in chronic myeloproliferative disorders.
Jauregui MP, Sanchez SR, Ewton AA, Rice L, Perkins SL, Dunphy CH, Chang CC. Jauregui MP, et al. Hum Pathol. 2008 Oct;39(10):1454-8. doi: 10.1016/j.humpath.2008.02.007. Epub 2008 Jul 11. Hum Pathol. 2008. PMID: 18619646
The erythroid and myeloid lineages showed absent to weak beta-catenin staining in most cases. In conclusion, these results indicate that the Wnt/beta-catenin signaling pathway may have a role in megakaryocytopoiesis in polycythemia vera and essential thrombocythemia. In ad …
The erythroid and myeloid lineages showed absent to weak beta-catenin staining in most cases. In conclusion, these results indicate that the …
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