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Successful treatment of hairy cell leukemia variant with rituximab.
Narat S, Gandla J, Dogan A, Mehta A. Narat S, et al. Leuk Lymphoma. 2005 Aug;46(8):1229-32. doi: 10.1080/10428190500083433. Leuk Lymphoma. 2005. PMID: 16085567
We report a case of a 53-year-old man who had refractory thrombocytopenia and lymphocytosis for 8 years. Investigations and analysis of spleen and bone marrow revealed a diagnosis of HCL variant. He opted for treatment with rituximab, a chimeric monocl …
We report a case of a 53-year-old man who had refractory thrombocytopenia and lymphocytosis for 8 years. Investigations and an …
Recurrent venous thromboembolic disease and factor XI concentrate in a patient with severe factor XI deficiency, chronic myelomonocytic leukaemia, factor V Leiden and heterozygous plasminogen deficiency.
Evans G, Pasi KJ, Mehta A, Lee CA, Perry DJ. Evans G, et al. Blood Coagul Fibrinolysis. 1997 Oct;8(7):437-40. doi: 10.1097/00001721-199710000-00009. Blood Coagul Fibrinolysis. 1997. PMID: 9391725
We describe the case of a 49 year-old man with chronic myelomonocytic leukaemia and severe factor XI deficiency (< 1 u/dl), in whom the use of factor XI concentrate appeared to be associated with the development of venous thromboembolic disease. ...Prothrombotic screeni …
We describe the case of a 49 year-old man with chronic myelomonocytic leukaemia and severe factor XI deficiency (< 1 u/dl), in who …
New developments in the management of Anderson-Fabry disease.
Mehta A. Mehta A. QJM. 2002 Oct;95(10):647-53. doi: 10.1093/qjmed/95.10.647. QJM. 2002. PMID: 12324636 Review.
Anderson-Fabry disease (AFD) is a rare, X-linked lysosomal storage disorder that leads to accumulation of globotriasylceramide throughout diverse cells, tissues and organs of the body. ...
Anderson-Fabry disease (AFD) is a rare, X-linked lysosomal storage disorder that leads to accumulation of globotriasylceramide throug …
MK 886, an antagonist of leukotriene generation, inhibits DNA synthesis in a subset of acute myeloid leukaemia cells.
Khan MA, Hoffbrand AV, Mehta A, Wright F, Tahami F, Wickremasinghe RG. Khan MA, et al. Leuk Res. 1993 Sep;17(9):759-62. doi: 10.1016/0145-2126(93)90109-x. Leuk Res. 1993. PMID: 8371575
Cells from a subset only of these patients were sensitive to MK 886, a potent selective inhibitor of leukotriene synthesis. By contrast, DNA replication in cells from all of the patients was inhibited by nordihydroguiaretic acid (NDGA), a leukotriene synthesi …
Cells from a subset only of these patients were sensitive to MK 886, a potent selective inhibitor of leukotriene synthesis. By …
Acute myeloblastic leukaemias of FAB types M6 and M4, with cryptic PML/RARalpha fusion gene formation, relapsing as acute promyelocytic leukaemia M3.
Virchis A, Massey E, Butler T, Devaraj P, Wright F, Secker-Walker L, Prentice HG, Mehta A. Virchis A, et al. Br J Haematol. 2001 Sep;114(3):551-6. doi: 10.1046/j.1365-2141.2001.02989.x. Br J Haematol. 2001. PMID: 11552979
Subsequent marrow dysplasia and an M6 relapse were accompanied by a new cytogenetic clone involving chromosomes X, 2, 4, 6, 7 and 16. ...FISH analysis showed this to be a three-way translocation involving chromosomes 15, 16 and 17 again with juxtaposition of PML and …
Subsequent marrow dysplasia and an M6 relapse were accompanied by a new cytogenetic clone involving chromosomes X, 2, 4, 6, 7 and 16. …
Minimal residual disease in acute lymphoblastic leukaemia--PCR analysis of immunoglobulin gene rearrangements.
Cole-Sinclair M, Foroni L, Wright F, Mehta A, Prentice HG, Hoffbrand AV. Cole-Sinclair M, et al. Leuk Lymphoma. 1993;11 Suppl 2:49-58. doi: 10.3109/10428199309064262. Leuk Lymphoma. 1993. PMID: 8124233
Rearrangement of the immunoglobulin heavy chain (IgH) gene can be utilized as a marker of clonality in a number of B-lineage lymphoproliferative disorders including acute lymphoblastic leukaemia (ALL). ...A gene "fingerprinting" modification of a previ …
Rearrangement of the immunoglobulin heavy chain (IgH) gene can be utilized as a marker of clonality in a number of B-lineage l …
Stages of T-cell receptor protein expression in T-cell acute lymphoblastic leukemia.
Campana D, van Dongen JJ, Mehta A, Coustan-Smith E, Wolvers-Tettero IL, Ganeshaguru K, Janossy G. Campana D, et al. Blood. 1991 Apr 1;77(7):1546-54. Blood. 1991. PMID: 1826223
E2A/HLF fusion cDNAs and the use of RT-PCR for the detection of minimal residual disease in t(17;19)(q22;p13) acute lymphoblastic leukemia.
Devaraj PE, Foroni L, Sekhar M, Butler T, Wright F, Mehta A, Samson D, Prentice HG, Hoffbrand AV, Secker-Walker LM. Devaraj PE, et al. Leukemia. 1994 Jul;8(7):1131-8. Leukemia. 1994. PMID: 7518549
Generation of osteoclasts from type 1 Gaucher patients and correlation with clinical and genetic features of disease.
Reed MC, Bauernfreund Y, Cunningham N, Beaton B, Mehta AB, Hughes DA. Reed MC, et al. Gene. 2018 Dec 15;678:196-206. doi: 10.1016/j.gene.2018.08.045. Epub 2018 Aug 9. Gene. 2018. PMID: 30099023
Gaucher disease (GD) is a rare autosomal recessive disorder caused by deficient activity of β-glucocerebrosidase resulting in the accumulation of glucosylceramide. ...A number of studies have shown some patients suffer bone events while receiving ERT. Studies of bio …
Gaucher disease (GD) is a rare autosomal recessive disorder caused by deficient activity of β-glucocerebrosidase resulting in the acc …
Selective apoptotic killing of malignant hemopoietic cells by antibody-targeted delivery of an amphipathic peptide.
Marks AJ, Cooper MS, Anderson RJ, Orchard KH, Hale G, North JM, Ganeshaguru K, Steele AJ, Mehta AB, Lowdell MW, Wickremasinghe RG. Marks AJ, et al. Cancer Res. 2005 Mar 15;65(6):2373-7. doi: 10.1158/0008-5472.CAN-04-2594. Cancer Res. 2005. PMID: 15781652
The alpha-helical amphipathic peptide D-(KLAKLAK)2 is toxic to eukaryotic cells if internalized by a suitable targeting mechanism. ...We therefore suggest that amphipathic peptides may be of value as targeted therapeutic agents for the treatment of a subset of hemat …
The alpha-helical amphipathic peptide D-(KLAKLAK)2 is toxic to eukaryotic cells if internalized by a suitable targeting mechanism. .. …
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