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Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot.
Finken M, Kirschner P, Meier A, Wrede A, Böttger EC. Finken M, et al. Mol Microbiol. 1993 Sep;9(6):1239-46. doi: 10.1111/j.1365-2958.1993.tb01253.x. Mol Microbiol. 1993. PMID: 7934937
The 16S rRNA region mutated perturbs a pseudoknot structure in a region which has been linked to ribosomal S12 protein....
The 16S rRNA region mutated perturbs a pseudoknot structure in a region which has been linked to ribosomal S12 protein....
Genetic basis for clarithromycin resistance among isolates of Mycobacterium chelonae and Mycobacterium abscessus.
Wallace RJ Jr, Meier A, Brown BA, Zhang Y, Sander P, Onyi GO, Böttger EC. Wallace RJ Jr, et al. Antimicrob Agents Chemother. 1996 Jul;40(7):1676-81. doi: 10.1128/AAC.40.7.1676. Antimicrob Agents Chemother. 1996. PMID: 8807061 Free PMC article.
Sequencing of the gene coding for the 23S rRNA peptidyltransferase region revealed a point mutation involving adenine at position 2058 (38%) or adenine at position 2059 (62%) in 20 of 20 relapse isolates from the first 13 patients identified. ...M. chelonae and M. abscessu …
Sequencing of the gene coding for the 23S rRNA peptidyltransferase region revealed a point mutation involving adenine at position 205 …
Correlation of molecular resistance mechanisms and phenotypic resistance levels in streptomycin-resistant Mycobacterium tuberculosis.
Meier A, Sander P, Schaper KJ, Scholz M, Böttger EC. Meier A, et al. Antimicrob Agents Chemother. 1996 Nov;40(11):2452-4. doi: 10.1128/AAC.40.11.2452. Antimicrob Agents Chemother. 1996. PMID: 8913445 Free PMC article.
Quantitative susceptibility testing of clinical isolates of streptomycin-resistant Mycobacterium tuberculosis demonstrated that there is a close correlation between the molecular resistance mechanism and the in vitro activity of streptomycin: mutations in rpsL were mainly …
Quantitative susceptibility testing of clinical isolates of streptomycin-resistant Mycobacterium tuberculosis demonstrated that there is …
Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population.
Meier A, Heifets L, Wallace RJ Jr, Zhang Y, Brown BA, Sander P, Böttger EC. Meier A, et al. J Infect Dis. 1996 Aug;174(2):354-60. doi: 10.1093/infdis/174.2.354. J Infect Dis. 1996. PMID: 8699066
Single-colony clones from cultures that were mixtures of more than one mutation revealed a single mutation within each clone. Pulsed field gel electrophoresis of genomic DNA restriction fragments revealed that 13 (81%) of 16 multiple mutations identified in the same patien …
Single-colony clones from cultures that were mixtures of more than one mutation revealed a single mutation within each clone. Pulsed …
Mycobacterium intermedium sp. nov.
Meier A, Kirschner P, Schröder KH, Wolters J, Kroppenstedt RM, Böttger EC. Meier A, et al. Int J Syst Bacteriol. 1993 Apr;43(2):204-9. doi: 10.1099/00207713-43-2-204. Int J Syst Bacteriol. 1993. PMID: 8494735
Strains of a new type of slowly growing mycobacterium were repeatedly isolated from sputum from a patient with pulmonary disease. ...The type strain is strain 1669/91; a culture of this strain has been deposited in the Deutsche Sammlung von Mikroorganismen un …
Strains of a new type of slowly growing mycobacterium were repeatedly isolated from sputum from a patient with pulmonary disea …
Identification of mutations in 23S rRNA gene of clarithromycin-resistant Mycobacterium intracellulare.
Meier A, Kirschner P, Springer B, Steingrube VA, Brown BA, Wallace RJ Jr, Böttger EC. Meier A, et al. Antimicrob Agents Chemother. 1994 Feb;38(2):381-4. doi: 10.1128/aac.38.2.381. Antimicrob Agents Chemother. 1994. PMID: 8192472 Free PMC article.
Nucleotide sequence comparisons of the peptidyltransferase region in 23S rRNAs from parental and resistant strains revealed that in three of six resistant strains, for which the MIC was > 32 micrograms/ml, a single base was mutated (Escherichia coli equivalent, A
Nucleotide sequence comparisons of the peptidyltransferase region in 23S rRNAs from parental and resistant strains revealed that in three of …
Elimination of contaminating DNA within polymerase chain reaction reagents: implications for a general approach to detection of uncultured pathogens.
Meier A, Persing DH, Finken M, Böttger EC. Meier A, et al. J Clin Microbiol. 1993 Mar;31(3):646-52. doi: 10.1128/JCM.31.3.646-652.1993. J Clin Microbiol. 1993. PMID: 8458958 Free PMC article.
Analysis based on comparisons of 16S rRNA sequences provides a rapid and reliable approach to identifying human pathogens. By directing oligonucleotide primers at sequences conserved throughout the eubacterial kingdom, bacterial 16S ribosomal DNA sequences of virtually any …
Analysis based on comparisons of 16S rRNA sequences provides a rapid and reliable approach to identifying human pathogens. By directi …
The role of ribosomal RNAs in macrolide resistance.
Sander P, Prammananan T, Meier A, Frischkorn K, Böttger EC. Sander P, et al. Mol Microbiol. 1997 Nov;26(3):469-80. doi: 10.1046/j.1365-2958.1997.5811946.x. Mol Microbiol. 1997. PMID: 9402018
Surprisingly, drug resistance was associated not with alterations in ribosomal proteins, but with a single point mutation in the peptidyltransferase region of one of the two 23S RNA genes, i.e. ...This mutation resulted in a heterozygous organism with a mutat …
Surprisingly, drug resistance was associated not with alterations in ribosomal proteins, but with a single point mutation in the pept …
Ribosomal drug resistance in mycobacteria.
Sander P, Meier A, Böttger EC. Sander P, et al. Res Microbiol. 1996 Jan-Feb;147(1-2):59-67. doi: 10.1016/0923-2508(96)80205-1. Res Microbiol. 1996. PMID: 8761724 Review. No abstract available.
Genetic alterations in streptomycin-resistant Mycobacterium tuberculosis: mapping of mutations conferring resistance.
Meier A, Kirschner P, Bange FC, Vogel U, Böttger EC. Meier A, et al. Antimicrob Agents Chemother. 1994 Feb;38(2):228-33. doi: 10.1128/aac.38.2.228. Antimicrob Agents Chemother. 1994. PMID: 8192448 Free PMC article.
Two isolates (3656 and 3976) showed a wild-type ribosomal protein, S12, but exhibited a single point mutation at 16S rRNA position 491 (C-->T) or 512 (C-->T), respectively. Sequence analysis of a third isolate (2438) revealed a single base change …
Two isolates (3656 and 3976) showed a wild-type ribosomal protein, S12, but exhibited a single point mutation at 16S rRNA posi …
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