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An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons.
Brandon EF, Raap CD, Meijerman I, Beijnen JH, Schellens JH. Brandon EF, et al. Among authors: meijerman i. Toxicol Appl Pharmacol. 2003 Jun 15;189(3):233-46. doi: 10.1016/s0041-008x(03)00128-5. Toxicol Appl Pharmacol. 2003. PMID: 12791308 Review.
Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures.
Mooiman KD, Maas-Bakker RF, Rosing H, Beijnen JH, Schellens JH, Meijerman I. Mooiman KD, et al. Among authors: meijerman i. Biomed Chromatogr. 2013 Sep;27(9):1107-16. doi: 10.1002/bmc.2913. Epub 2013 May 14. Biomed Chromatogr. 2013. PMID: 23674377
PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line.
Harmsen S, Meijerman I, Febus CL, Maas-Bakker RF, Beijnen JH, Schellens JH. Harmsen S, et al. Among authors: meijerman i. Cancer Chemother Pharmacol. 2010 Sep;66(4):765-71. doi: 10.1007/s00280-009-1221-4. Epub 2009 Dec 30. Cancer Chemother Pharmacol. 2010. PMID: 20041327 Free PMC article.
Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor.
Harmsen S, Meijerman I, Beijnen JH, Schellens JH. Harmsen S, et al. Among authors: meijerman i. Cancer Chemother Pharmacol. 2009 Jun;64(1):35-43. doi: 10.1007/s00280-008-0842-3. Epub 2008 Oct 7. Cancer Chemother Pharmacol. 2009. PMID: 18839173
The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology.
Harmsen S, Meijerman I, Beijnen JH, Schellens JH. Harmsen S, et al. Among authors: meijerman i. Cancer Treat Rev. 2007 Jun;33(4):369-80. doi: 10.1016/j.ctrv.2007.02.003. Epub 2007 Apr 23. Cancer Treat Rev. 2007. PMID: 17451886 Review.
Comparison of two immortalized human cell lines to study nuclear receptor-mediated CYP3A4 induction.
Harmsen S, Koster AS, Beijnen JH, Schellens JH, Meijerman I. Harmsen S, et al. Among authors: meijerman i. Drug Metab Dispos. 2008 Jun;36(6):1166-71. doi: 10.1124/dmd.107.017335. Epub 2008 Mar 17. Drug Metab Dispos. 2008. PMID: 18347084
Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines.
Brandon EF, Bosch TM, Deenen MJ, Levink R, van der Wal E, van Meerveld JB, Bijl M, Beijnen JH, Schellens JH, Meijerman I. Brandon EF, et al. Among authors: meijerman i. Toxicol Appl Pharmacol. 2006 Feb 15;211(1):1-10. doi: 10.1016/j.taap.2005.05.004. Epub 2005 Jun 21. Toxicol Appl Pharmacol. 2006. PMID: 15975613
The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.
Mooiman KD, Goey AK, Huijbregts TJ, Maas-Bakker RF, Beijnen JH, Schellens JH, Meijerman I. Mooiman KD, et al. Among authors: meijerman i. J Pharm Pharmacol. 2014 Sep;66(9):1339-46. doi: 10.1111/jphp.12259. Epub 2014 Apr 15. J Pharm Pharmacol. 2014. PMID: 24730468
The effect of complementary and alternative medicines on CYP3A4-mediated metabolism of three different substrates: 7-benzyloxy-4-trifluoromethyl-coumarin, midazolam and docetaxel.
Mooiman KD, Maas-Bakker RF, Hendrikx JJ, Bank PC, Rosing H, Beijnen JH, Schellens JH, Meijerman I. Mooiman KD, et al. Among authors: meijerman i. J Pharm Pharmacol. 2014 Jun;66(6):865-74. doi: 10.1111/jphp.12208. Epub 2014 Jan 7. J Pharm Pharmacol. 2014. PMID: 24392691
Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients.
Goey AK, Mooiman KD, Beijnen JH, Schellens JH, Meijerman I. Goey AK, et al. Among authors: meijerman i. Cancer Treat Rev. 2013 Nov;39(7):773-83. doi: 10.1016/j.ctrv.2012.12.008. Epub 2013 Feb 8. Cancer Treat Rev. 2013. PMID: 23394826 Review.
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