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Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction.
Boslem E, Meikle PJ, Biden TJ. Boslem E, et al. Among authors: meikle pj. Islets. 2012 May-Jun;4(3):177-87. doi: 10.4161/isl.20102. Islets. 2012. PMID: 22847494 Free PMC article. Review.
Reconstituted high-density lipoprotein infusion modulates fatty acid metabolism in patients with type 2 diabetes mellitus.
Drew BG, Carey AL, Natoli AK, Formosa MF, Vizi D, Reddy-Luthmoodoo M, Weir JM, Barlow CK, van Hall G, Meikle PJ, Duffy SJ, Kingwell BA. Drew BG, et al. Among authors: meikle pj. J Lipid Res. 2011 Mar;52(3):572-81. doi: 10.1194/jlr.P012518. Epub 2011 Jan 11. J Lipid Res. 2011. PMID: 21224289 Free PMC article. Clinical Trial.
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.
Boslem E, MacIntosh G, Preston AM, Bartley C, Busch AK, Fuller M, Laybutt DR, Meikle PJ, Biden TJ. Boslem E, et al. Among authors: meikle pj. Biochem J. 2011 Apr 1;435(1):267-76. doi: 10.1042/BJ20101867. Biochem J. 2011. PMID: 21265737
Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids.
Lam YY, Hatzinikolas G, Weir JM, Janovská A, McAinch AJ, Game P, Meikle PJ, Wittert GA. Lam YY, et al. Among authors: meikle pj. Biochim Biophys Acta. 2011 Jul-Aug;1811(7-8):468-75. doi: 10.1016/j.bbalip.2011.04.011. Epub 2011 May 5. Biochim Biophys Acta. 2011. PMID: 21570480
Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes.
Barber MN, Risis S, Yang C, Meikle PJ, Staples M, Febbraio MA, Bruce CR. Barber MN, et al. Among authors: meikle pj. PLoS One. 2012;7(7):e41456. doi: 10.1371/journal.pone.0041456. Epub 2012 Jul 25. PLoS One. 2012. PMID: 22848500 Free PMC article. Clinical Trial.
Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice.
Bruce CR, Risis S, Babb JR, Yang C, Kowalski GM, Selathurai A, Lee-Young RS, Weir JM, Yoshioka K, Takuwa Y, Meikle PJ, Pitson SM, Febbraio MA. Bruce CR, et al. Among authors: meikle pj. Diabetes. 2012 Dec;61(12):3148-55. doi: 10.2337/db12-0029. Epub 2012 Sep 6. Diabetes. 2012. PMID: 22961081 Free PMC article.
Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance.
Boon J, Hoy AJ, Stark R, Brown RD, Meex RC, Henstridge DC, Schenk S, Meikle PJ, Horowitz JF, Kingwell BA, Bruce CR, Watt MJ. Boon J, et al. Among authors: meikle pj. Diabetes. 2013 Feb;62(2):401-10. doi: 10.2337/db12-0686. Epub 2012 Nov 8. Diabetes. 2013. PMID: 23139352 Free PMC article.
Skeletal muscle insulin resistance associated with cholesterol-induced activation of macrophages is prevented by high density lipoprotein.
Carey AL, Siebel AL, Reddy-Luthmoodoo M, Natoli AK, D'Souza W, Meikle PJ, Sviridov D, Drew BG, Kingwell BA. Carey AL, et al. Among authors: meikle pj. PLoS One. 2013;8(2):e56601. doi: 10.1371/journal.pone.0056601. Epub 2013 Feb 21. PLoS One. 2013. PMID: 23437184 Free PMC article.
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding.
Turner N, Kowalski GM, Leslie SJ, Risis S, Yang C, Lee-Young RS, Babb JR, Meikle PJ, Lancaster GI, Henstridge DC, White PJ, Kraegen EW, Marette A, Cooney GJ, Febbraio MA, Bruce CR. Turner N, et al. Among authors: meikle pj. Diabetologia. 2013 Jul;56(7):1638-48. doi: 10.1007/s00125-013-2913-1. Epub 2013 Apr 26. Diabetologia. 2013. PMID: 23620060
Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells.
Boslem E, Weir JM, MacIntosh G, Sue N, Cantley J, Meikle PJ, Biden TJ. Boslem E, et al. Among authors: meikle pj. J Biol Chem. 2013 Sep 13;288(37):26569-82. doi: 10.1074/jbc.M113.489310. Epub 2013 Jul 29. J Biol Chem. 2013. PMID: 23897822 Free PMC article.
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